(3S,4S)-3-Hydroxy-6-methyl-4-{2-[(S)-2-(3-methyl-butyrylamino)-3-phenyl-propylsulfanyl]-3-phenyl-propionylamino}-heptanoic acid {(S)-1-[(S)-1-((S)-2-benzylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-ethyl}-amide

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Chemical Name:(3S,4S)-3-Hydroxy-6-methyl-4-{2-[(S)-2-(3-methyl-butyrylamino)-3-phenyl-propylsulfanyl]-3-phenyl-propionylamino}-heptanoic acid {(S)-1-[(S)-1-((S)-2-benzylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-ethyl}-amide
CAS No.:118388-46-8
Molecular Formula:C₄₉H₇₁N₅O₇S
Molecular Weight:874.198
Hs Code.:

(3S,4S)-3-Hydroxy-6-methyl-4-{2-[(S)-2-(3-methyl-butyrylamino)-3-phenyl-propylsulfanyl]-3-phenyl-propionylamino}-heptanoic acid {(S)-1-[(S)-1-((S)-2-benzylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-ethyl}-amide

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Chemical Property of (3S,4S)-3-Hydroxy-6-methyl-4-{2-[(S)-2-(3-methyl-butyrylamino)-3-phenyl-propylsulfanyl]-3-phenyl-propionylamino}-heptanoic acid {(S)-1-[(S)-1-((S)-2-benzylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-ethyl}-amide

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Technology Process of (3S,4S)-3-Hydroxy-6-methyl-4-{2-[(S)-2-(3-methyl-butyrylamino)-3-phenyl-propylsulfanyl]-3-phenyl-propionylamino}-heptanoic acid {(S)-1-[(S)-1-((S)-2-benzylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-ethyl}-amide

There total 5 articles about (3S,4S)-3-Hydroxy-6-methyl-4-{2-[(S)-2-(3-methyl-butyrylamino)-3-phenyl-propylsulfanyl]-3-phenyl-propionylamino}-heptanoic acid {(S)-1-[(S)-1-((S)-2-benzylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-ethyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 118387-88-5,124266-98-4,124267-04-5
2-[(S)-2-(3-Methyl-butyrylamino)-3-phenyl-propylsulfanyl]-3-phenyl-propionic acid

: 118387-69-2
Sta-Ala-Sta-NHCH₂Ph

: 118388-46-8,124339-10-2,124339-37-3
(3S,4S)-3-Hydroxy-6-methyl-4-{2-[(S)-2-(3-methyl-butyrylamino)-3-phenyl-propylsulfanyl]-3-phenyl-propionylamino}-heptanoic acid {(S)-1-[(S)-1-((S)-2-benzylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-ethyl}-amide

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm00164a058

Reference yield:

: 73058-30-7
(2S)-2-benzylazacyclopropane

: 118388-46-8,124339-10-2,124339-37-3
(3S,4S)-3-Hydroxy-6-methyl-4-{2-[(S)-2-(3-methyl-butyrylamino)-3-phenyl-propylsulfanyl]-3-phenyl-propionylamino}-heptanoic acid {(S)-1-[(S)-1-((S)-2-benzylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-ethyl}-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / H₂S / ethanol / from -78 deg C to room temp.

2: 82 percent / liq. NH₃ / overnight

3: 59 percent / Et₃N / CH₂Cl₂ / 0 °C

4: 57 percent / trifluoroacetic acid

5: 59 percent / HOBT/DCC, Et₃N / dimethylformamide; CH₂Cl₂ / 0 - 20 °C

With hydrogen sulfide; ammonia; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00164a058

Reference yield:

: 116264-32-5
(S)-2-amino-3-phenyl-1-propanethiol

: 118388-46-8,124339-10-2,124339-37-3
(3S,4S)-3-Hydroxy-6-methyl-4-{2-[(S)-2-(3-methyl-butyrylamino)-3-phenyl-propylsulfanyl]-3-phenyl-propionylamino}-heptanoic acid {(S)-1-[(S)-1-((S)-2-benzylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-ethyl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / liq. NH₃ / overnight

2: 59 percent / Et₃N / CH₂Cl₂ / 0 °C

3: 57 percent / trifluoroacetic acid

4: 59 percent / HOBT/DCC, Et₃N / dimethylformamide; CH₂Cl₂ / 0 - 20 °C

With ammonia; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00164a058