(4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-4,6-dichloro-phenoxymethyl}-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-ol

Base Information

Chemical Name:(4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-4,6-dichloro-phenoxymethyl}-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-ol
CAS No.:136007-36-8
Molecular Formula:C₄₃H₄₄Cl₂F₂O₄Si
Molecular Weight:761.808
Hs Code.:

(4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-4,6-dichloro-phenoxymethyl}-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-ol

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Chemical Property of (4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-4,6-dichloro-phenoxymethyl}-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-ol

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Technology Process of (4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-4,6-dichloro-phenoxymethyl}-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-ol

There total 11 articles about (4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-4,6-dichloro-phenoxymethyl}-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 455-84-5
4-fluoro-3-methylbonzoyl chloride

: 136007-36-8,136008-21-4
(4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-4,6-dichloro-phenoxymethyl}-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: NaOH / H₂O / 0.5 h

2: AlCl₃ / 2 h / 150 °C

3: tetrahydrofuran

4: H₂, conc. HCl / 10percent Pd/C / acetic acid / 1.5 h / 25 °C / 750.06 Torr

5: K₂CO₃, hydroquinone / dimethylsulfoxide / 3 h / 70 °C

6: glacial acetic acid / tetrahydrofuran / 72 h / Heating

With hydrogenchloride; sodium hydroxide; aluminium trichloride; hydrogen; potassium carbonate; acetic acid; hydroquinone; palladium on activated charcoal; In tetrahydrofuran; water; acetic acid; dimethyl sulfoxide;
DOI:10.1021/jm00114a004

Reference yield:

: 82297-89-0
(4-fluoro-3-methyl)phenylmagnesium bromide

: 136007-36-8,136008-21-4
(4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-4,6-dichloro-phenoxymethyl}-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran

2: H₂, conc. HCl / 10percent Pd/C / acetic acid / 1.5 h / 25 °C / 750.06 Torr

3: K₂CO₃, hydroquinone / dimethylsulfoxide / 3 h / 70 °C

4: glacial acetic acid / tetrahydrofuran / 72 h / Heating

With hydrogenchloride; hydrogen; potassium carbonate; acetic acid; hydroquinone; palladium on activated charcoal; In tetrahydrofuran; acetic acid; dimethyl sulfoxide;
DOI:10.1021/jm00114a004

Reference yield:

: (3,5-Dichloro-2-hydroxy-phenyl)-(4-fluoro-3-methyl-phenyl)-methanone

: 136007-36-8,136008-21-4
(4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-4,6-dichloro-phenoxymethyl}-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran

2: H₂, conc. HCl / 10percent Pd/C / acetic acid / 1.5 h / 25 °C / 750.06 Torr

3: K₂CO₃, hydroquinone / dimethylsulfoxide / 3 h / 70 °C

4: glacial acetic acid / tetrahydrofuran / 72 h / Heating

With hydrogenchloride; hydrogen; potassium carbonate; acetic acid; hydroquinone; palladium on activated charcoal; In tetrahydrofuran; acetic acid; dimethyl sulfoxide;
DOI:10.1021/jm00114a004