[3-Phenyl-cyclohex-(E)-ylidene]-acetic acid

Base Information

• Chemical Name: [3-Phenyl-cyclohex-(E)-ylidene]-acetic acid
• CAS No.: 111945-94-9
• Molecular Formula: C₁₄H₁₆O₂
• Molecular Weight: 216.28
• Mol file: 111945-94-9.mol

Synonyms:

Chemical Property of [3-Phenyl-cyclohex-(E)-ylidene]-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-Phenyl-cyclohex-(E)-ylidene]-acetic acid

There total 5 articles about [3-Phenyl-cyclohex-(E)-ylidene]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxy-5-phenylcyclohex-2-en-1-one (35376-44-4) → [3-Phenyl-cyclohex-(E)-ylidene]-acetic acid (111945-94-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 67 percent / sodium methoxide / methanol / 4 h / Heating

2: 66 percent / hydrogen / palladium dichloride, activated carbon / methanol; aq. HCl

3: sodium hydride / dimethylformamide / 1) 20 deg C, 1 h, 2) 90 deg C to 100 deg C, 8 h

4: sodium hydroxide / ethanol; H₂O / 5 h / Heating

With sodium hydroxide; hydrogen; sodium methylate; sodium hydride; pyrographite; palladium dichloride; In hydrogenchloride; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

3-methoxy-5-phenylcyclohex-2-ene-1-one (55815-00-4) → [3-Phenyl-cyclohex-(E)-ylidene]-acetic acid (111945-94-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / hydrogen / palladium dichloride, activated carbon / methanol; aq. HCl

2: sodium hydride / dimethylformamide / 1) 20 deg C, 1 h, 2) 90 deg C to 100 deg C, 8 h

3: sodium hydroxide / ethanol; H₂O / 5 h / Heating

With sodium hydroxide; hydrogen; sodium hydride; pyrographite; palladium dichloride; In hydrogenchloride; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

1-Phenylbut-1-en-3-one (122-57-6) → [3-Phenyl-cyclohex-(E)-ylidene]-acetic acid (111945-94-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 86 percent / sodium methoxide / methanol

2: 67 percent / sodium methoxide / methanol / 4 h / Heating

3: 66 percent / hydrogen / palladium dichloride, activated carbon / methanol; aq. HCl

4: sodium hydride / dimethylformamide / 1) 20 deg C, 1 h, 2) 90 deg C to 100 deg C, 8 h

5: sodium hydroxide / ethanol; H₂O / 5 h / Heating

With sodium hydroxide; hydrogen; sodium methylate; sodium hydride; pyrographite; palladium dichloride; In hydrogenchloride; methanol; ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

ethyl (3-phenylcyclohexylidene)acetate

3-phenylcyclohexanone

3-hydroxy-5-phenylcyclohex-2-en-1-one

3-methoxy-5-phenylcyclohex-2-ene-1-one