55815-00-4

Upstream product

• 186581-53-3 diazomethane 
• 493-72-1 5-phenyl-cyclohexane-1,3-dione 
• 67-56-1 methanol 
• 74-88-4 methyl iodide 
• 35376-44-4 3-hydroxy-5-phenylcyclohex-2-en-1-one 
• 149-73-5 trimethyl orthoformate 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 35376-41-1 5-phenylcyclohex-2-en-1-one 
• 100712-02-5 2-bromo-3-methoxy-5-phenylcyclohex-2-en-1-one 
• 36745-40-1 3-methyl-6-phenyl-6,7-dihydro-1-benzofuran-4(5H)-one 
• 1197361-60-6 3-methoxy-6-(2-nitro-1-phenylethyl)-5-phenyl-2-cyclohexen-1-one 
• 111945-94-9 [3-Phenyl-cyclohex-(E)-ylidene]-acetic acid 
• 198132-51-3 ethyl (3-phenylcyclohexylidene)acetate 
• 108062-26-6 (3-phenyl-cyclohexyl)-acetic acid 
• 68670-31-5 (3-Phenyl-cyclohexyl)-acetic acid methyl ester 
• 342894-10-4 3-Methoxy-5-phenyl-cyclohex-2-enone oxime 
• 20795-53-3 3-phenylcyclohexanone 

Relevant academic research and scientific papers

Regioselectivity of birch reductive alkylation of biaryls

(Chemical Equation Presented) The regioselectivity of the Birch reductive alkylation of polysubstituted biaryls has been investigated. Results indicate that regioselectivity is affected by the electronic nature of substituents on both aromatic rings. The

Organofluorine chemistry: Difluoromethylene motifs spaced 1,3 to each other imparts facial polarity to a cyclohexane ring

2,2-Dimethyl-5-phenyl-1,1,3,3-tetrafluororocyclohexane has been prepared and characterised as an example of a facially polarised cyclohexane containing 1,3 related CF2 groups. The dipolar nature of the ring arises from the axial orientation of

Formation of meta-Substituted Phenols by Transition Metal-Free Aromatization: Use of 2-Bromocyclohex-2-en-1-ones

Addition of Grignard or other organometallic reagents to 2-halocyclohex-2-en-1-ones bearing an alkyl or aryl group at C-5, followed by mild acid treatment and exposure to 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) at room temperature, generates meta-substituted phenols in which the newly introduced meta substituent originates from the Grignard reagent. The range of effective organometallic reagents includes alkyl, allyl, alkynyl, aryl, and heteroaryl compounds including those with fluorine substituents. The initial halocyclohexenone can be deprotonated at C-6 and reacted with carbon, fluorine, or sulfur electrophiles before the Grignard addition so as to generate highly substituted phenols.

Titanium(III) chloride mediated synthesis of furan derivatives: Synthesis of (±)-evodone

Titanocene(III) chloride (Cp2TiCl) mediated one-pot synthesis of furan derivatives has been accomplished. This radical method has been applied for the synthesis of a furanomonoterpene, evodone. Ti(III) species was prepared in situ from commercially available titanocene dichloride (Cp2TiCl 2) and zinc dust in THF. Indian Academy of Sciences.

Cyclic hydroxamic acids

This invention is related to a cyclic hydroxamic acid of the formula: STR1 wherein R1 is C1-24 alkyl and R2 is benzyl.

CYCLIC HYDROXAMIC ACIDS

Novel cyclic hydroxamic acids of the general formula: wherein ring A is 5- or 6-membered; R1, R2 and R3 each, independently, is hydrogen, C1-24 alkyl, C2-24 alkenyl or a group of the formula: wherein R4, R5, R7 and R8 each, independently is hydrogen, C1-4

SYNTHESIS OF CYCLOHEXYLALIPHATIC ACIDS AND THEIR PHARMACOLOGICAL PROPERTIES

A series of substituted cyclohexylacetic acids I has been obtained by hydrogenation of the unsaturated analogues II and III.Esters of these analogues were prepared by the Horner-Wittig reaction of the corresponding cyclohexanones IV and/or 2-cyclohexenones V with triethyl phosphonoacetate.These esters were obtained in two isomeric forms (Z and E), differing in the double bond in the exo-position.The derivatives with a substituent in the 2-position exhibited a partial shift of the double bond to the cyclohexane ring; this shift was especially marked in the 2-phenyl derivative.With the acids I-III, activation of fibrinolysis was assessed by the hanging clot method; the anti-inflammatory effect was assessed by inhibition of two experimental model inflammations.The regression equation relating fibrinolytic capacity to lipophilicity was a quadratic one, the logarithm of optimum lipophilicity being log Popt = 5.55.A qualitative assessment of the anti-inflammatory effect in relation to lipophilicity suggests that log Popt is probably higher than with arylaliphatic acids.These acids seem to have an active site different from that of the acids I-III.