4(e)-chloroadamantanone

Base Information

• Chemical Name: 4(e)-chloroadamantanone
• CAS No.: 64937-57-1
• Molecular Formula: C₁₀H₁₃ClO
• Molecular Weight: 184.666
• Mol file: 64937-57-1.mol

Synonyms:

Chemical Property of 4(e)-chloroadamantanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4(e)-chloroadamantanone

There total 18 articles about 4(e)-chloroadamantanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

endo-Bicyclo<3.3.1>non-6-ene-3-carboxylic acid (21932-98-9) → 4-Hydroxyadamantan-2-on (51020-64-5) + 4-chloroeq-adamantan-2-one (19213-96-8,19301-54-3,19543-61-4,56781-81-8,56781-82-9,64937-56-0,64937-57-1) + 4-chloroax-adamantan-2-one (19213-96-8,19301-54-3,19543-61-4,56781-81-8,56781-82-9,64937-56-0,64937-57-1)

Guidance literature:

With hydrogenchloride; In n-heptane; at 120 ℃; for 24h;

DOI:10.1002/poc.1247

Reference yield: 36.0%

endo-Bicyclo<3.3.1>non-6-ene-3-carboxylic acid (21932-98-9) → 4-Hydroxyadamantan-2-on (51020-64-5) + 4-chloroeq-adamantan-2-one (19213-96-8,19301-54-3,19543-61-4,56781-81-8,56781-82-9,64937-56-0,64937-57-1) + 4-chloroax-adamantan-2-one (19213-96-8,19301-54-3,19543-61-4,56781-81-8,56781-82-9,64937-56-0,64937-57-1)

Guidance literature:

With hydrogenchloride; In n-heptane; at 120 ℃; for 24h;

DOI:10.1002/poc.1247

Reference yield: 21.0%

tert.-butyl lithium (594-19-4) → 7-endo-pivaloylbicyclo(3.3.1)non-2-ene (95935-36-7,96038-23-2,132340-41-1) + 7-endo-(di-tert-butylhydroxymethyl)bicyclo-(3.3.1)non-2-ene (132259-84-8) + 2,11,11-trimethyl-15-oxa-2,4-ethanoadamantane (132156-54-8) + 4e-chloroadamantan-2-one (19213-96-8,19301-54-3,19543-61-4,56781-81-8,56781-82-9,64937-56-0,64937-57-1)

Guidance literature:

In diethyl ether; pentane; Ambient temperature;

DOI:10.1021/jo00005a011

upstream raw materials:

4-oxohomoadamantan-5-one

4e-Chlor-adamantanon-(2)

4^e-chloro-2-adamantanone

2-Adamantanone

Downstream raw materials:

4e-Chlor-adamantanon-(2)

2,2,4^e-trichloroadamantane

4^e-chloro-2-adamantanone

2,2,4^a-trichloroadamantane