(R*,RS)-methyl 2-<<2'-tert-butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>ethoxy>methyl>prop-2-enoate

Base Information

• Chemical Name: (R*,RS)-methyl 2-<<2'-tert-butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>ethoxy>methyl>prop-2-enoate
• CAS No.: 145745-80-8
• Molecular Formula: C₂₉H₅₀O₆S₂Si₂
• Molecular Weight: 615.015
• Mol file: 145745-80-8.mol

Synonyms:

Chemical Property of (R*,RS)-methyl 2-<<2'-tert-butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>ethoxy>methyl>prop-2-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R*,RS)-methyl 2-<<2'-tert-butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>ethoxy>methyl>prop-2-enoate

There total 9 articles about (R*,RS)-methyl 2-<<2'-tert-butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>ethoxy>methyl>prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-2-hydroxymethyl-2-[(dimethylphenylsilyl)methylene]ethanal (119481-06-0) → (R*,RS)-methyl 2-<<2'-tert-butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>ethoxy>methyl>prop-2-enoate (145745-80-8,145746-08-3)

Guidance literature:

Multi-step reaction with 4 steps

1: KH₂PO₄, K₂HPO₄, NaClO₂, 2-methylbut-2-ene / 2-methyl-propan-2-ol; H₂O / 1.5 h / 30 °C

2: CH₂Cl₂

3: 69 percent / N-bromosuccinimide, triphenylphosphine / CH₂Cl₂ / 25 °C

4: 1) KH / 1) THF, room temperature, 1 h, 2) THF, a) 0 deg C, 20 min, b) room temperature, 10 min

With sodium chlorite; dipotassium hydrogenphosphate; potassium dihydrogenphosphate; N-Bromosuccinimide; 2-methyl-but-2-ene; potassium hydride; triphenylphosphine; In dichloromethane; water; tert-butyl alcohol;

DOI:10.1039/P19920002735

Reference yield:

(E)-3-(Dimethyl-phenyl-silanyl)-2-hydroxymethyl-acrylic acid → (R*,RS)-methyl 2-<<2'-tert-butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>ethoxy>methyl>prop-2-enoate (145745-80-8,145746-08-3)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂

2: 69 percent / N-bromosuccinimide, triphenylphosphine / CH₂Cl₂ / 25 °C

3: 1) KH / 1) THF, room temperature, 1 h, 2) THF, a) 0 deg C, 20 min, b) room temperature, 10 min

With N-Bromosuccinimide; potassium hydride; triphenylphosphine; In dichloromethane;

DOI:10.1039/P19920002735

Reference yield:

(E)-methyl 3-dimethyl(phenyl)silyl-2-hydroxymethylprop-2-enoate (145746-07-2) → (R*,RS)-methyl 2-<<2'-tert-butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>ethoxy>methyl>prop-2-enoate (145745-80-8,145746-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / N-bromosuccinimide, triphenylphosphine / CH₂Cl₂ / 25 °C

2: 1) KH / 1) THF, room temperature, 1 h, 2) THF, a) 0 deg C, 20 min, b) room temperature, 10 min

With N-Bromosuccinimide; potassium hydride; triphenylphosphine; In dichloromethane;

DOI:10.1039/P19920002735

upstream raw materials:

(Z)-methyl 2-bromomethyl-3-dimethyl(phenyl)silylprop-2-enoate

2-tert-butyldimethylsiloxy-1-<2'-(2'',2''-dimethoxyethyl)-1',3'-dithian-2'-yl>ethanol

tert-butyldimethylsiloxyacetaldehyde

Allyloxy-tert-butyl-dimethyl-silane