3-quinuclidinyl benzilate

Base Information

• Chemical Name: 3-quinuclidinyl benzilate
• CAS No.: 138740-54-2
• Molecular Formula: C₁₄H₁₉NO
• Molecular Weight: 217.311
• Mol file: 138740-54-2.mol

Synonyms:

Chemical Property of 3-quinuclidinyl benzilate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-quinuclidinyl benzilate

There total 7 articles about 3-quinuclidinyl benzilate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

iodomethylbenzene (620-05-3) + 3-quinuclidinol (1619-34-7) → 3-quinuclidinyl benzilate (138740-54-2,138740-56-4,138740-57-5)

Guidance literature:

3-quinuclidinol; With sodium hydride; In N,N-dimethyl-formamide; for 2h; Inert atmosphere;

iodomethylbenzene; In N,N-dimethyl-formamide; acetonitrile; at 90 ℃; for 15h; Inert atmosphere;

DOI:10.1080/00397911.2019.1568498

Reference yield:

3-benzyloxy-1-aza-bicyclo[2.2.2]octane; compound with borane → 3-quinuclidinyl benzilate (138740-54-2,138740-56-4,138740-57-5)

Guidance literature:

With hydrogenchloride; In acetone;

DOI:10.1016/j.bmcl.2004.04.091

Reference yield:

benzyl chloride (100-44-7) → 3-quinuclidinyl benzilate (138740-54-2,138740-56-4,138740-57-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide

2: aq. HCl / acetone

With hydrogenchloride; sodium hydride; In N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.bmcl.2004.04.091

upstream raw materials:

benzyl chloride

benzyl alcohol

iodomethylbenzene

3-quinuclidinol

Downstream raw materials:

(S)-3-(benzyloxy)-1-aza-bicyclo[2.2.2]octane

(R)-3-benzyloxy-1-aza-bicyclo[2.2.2]octane