Chemical Property of 3-Quinuclidinol
Chemical Property:
- Appearance/Colour:Crystalline solid
- Vapor Pressure:0.0545mmHg at 25°C
- Melting Point:220-223 °C(lit.)
- Refractive Index:1.4790 (estimate)
- Boiling Point:206.9 °C at 760 mmHg
- PKA:14.75±0.20(Predicted)
- Flash Point:97.7 °C
- PSA：23.47000
- Density:1.13 g/cm3
- LogP:0.01080
- Storage Temp.:2-8°C
- Sensitive.:Air Sensitive
- Water Solubility.:soluble
- XLogP3:0.2
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:0
- Exact Mass:127.099714038
- Heavy Atom Count:9
- Complexity:108
- Purity/Quality:
-
99%, *data from raw suppliers
3-Quinuclidinol *data from reagent suppliers
Safty Information:
- Pictogram(s):
F, 
C
- Hazard Codes:C,F
- Statements:
34-11
- Safety Statements:
26-36/37/39-45-16
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1CN2CCC1C(C2)O
-
Uses
Hypotensive. Synthon for preparation of cholinergic receptor ligands and anesthetics 3-Quinuclidinol acts as a chiral building block for various antimuscarinic agents and other active pharmaceutical ingredients. It serves as a catalyst for condensation of methyl vinyl ketone with aldehydes. It is also used as a reagent for cleavage of beta-keto and vinylogous beta-keto esters. Further, it plays an important role as a synthon in the preparation of cholinergic receptor ligands and anesthetics. In addition to this, it is used in chemoselective alfa-iodination of acrylic esters through Morita-Baylis-Hillman reaction.
