(1R,3aS,7aR)-4-[2-{(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-[3-(tert-butyl-dimethyl-silanyloxy)-propoxy]-cyclohexylidene}-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-7a-methyl-octahydro-indene

Base Information

Chemical Name:(1R,3aS,7aR)-4-[2-{(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-[3-(tert-butyl-dimethyl-silanyloxy)-propoxy]-cyclohexylidene}-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-7a-methyl-octahydro-indene
CAS No.:160399-86-0
Molecular Formula:C₅₃H₁₀₆O₅Si₄
Molecular Weight:935.764
Hs Code.:

(1R,3aS,7aR)-4-[2-{(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-[3-(tert-butyl-dimethyl-silanyloxy)-propoxy]-cyclohexylidene}-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-7a-methyl-octahydro-indene

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Chemical Property of (1R,3aS,7aR)-4-[2-{(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-[3-(tert-butyl-dimethyl-silanyloxy)-propoxy]-cyclohexylidene}-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-7a-methyl-octahydro-indene

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Technology Process of (1R,3aS,7aR)-4-[2-{(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-[3-(tert-butyl-dimethyl-silanyloxy)-propoxy]-cyclohexylidene}-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-7a-methyl-octahydro-indene

There total 22 articles about (1R,3aS,7aR)-4-[2-{(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-[3-(tert-butyl-dimethyl-silanyloxy)-propoxy]-cyclohexylidene}-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-7a-methyl-octahydro-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 994-30-9
triethylsilyl chloride

: 160399-86-0,160399-87-1
(1R,3aS,7aR)-4-[2-{(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-[3-(tert-butyl-dimethyl-silanyloxy)-propoxy]-cyclohexylidene}-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-7a-methyl-octahydro-indene

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / imidazole / dimethylformamide / 2 h / Ambient temperature

2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 2.) THF, hexane, a) -78 deg C, 1 h, b) RT, 18 h

3: aq. AcOH, THF / 4.5 h / Ambient temperature

4: NaH, 18-crown-6 / dimethylformamide / 48 h / Ambient temperature

With tetrahydrofuran; 1H-imidazole; n-butyllithium; 18-crown-6 ether; sodium hydride; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00048a009

Reference yield:

: 994-30-9
triethylsilyl chloride

: 160399-86-0,160399-87-1
(1R,3aS,7aR)-4-[2-{(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-[3-(tert-butyl-dimethyl-silanyloxy)-propoxy]-cyclohexylidene}-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-7a-methyl-octahydro-indene

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / imidazole / dimethylformamide / 2 h / Ambient temperature

2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 2.) THF, hexane, a) -78 deg C, 1 h, b) RT, 18 h

3: 38 percent / aq. AcOH, THF / 4.5 h / Ambient temperature

4: NaH, 18-crown-6 / dimethylformamide / 48 h / Ambient temperature

With tetrahydrofuran; 1H-imidazole; n-butyllithium; 18-crown-6 ether; sodium hydride; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00048a009

Reference yield:

: 70550-73-1
(1R,3aR,7aR)-1-[(2R)-6-hydroxy-6-methylhept-2-yl]-7a-methyloctahydroinden-4-one

: 160399-86-0,160399-87-1
(1R,3aS,7aR)-4-[2-{(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-[3-(tert-butyl-dimethyl-silanyloxy)-propoxy]-cyclohexylidene}-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-7a-methyl-octahydro-indene

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / imidazole / dimethylformamide / 2 h / Ambient temperature

2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 2.) THF, hexane, a) -78 deg C, 1 h, b) RT, 18 h

3: aq. AcOH, THF / 4.5 h / Ambient temperature

4: NaH, 18-crown-6 / dimethylformamide / 48 h / Ambient temperature

With tetrahydrofuran; 1H-imidazole; n-butyllithium; 18-crown-6 ether; sodium hydride; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00048a009