Technology Process of (3aS,7aR)-3-[(S)-1-((S)-Benzenesulfinyl)-ethyl]-7-methoxy-3a,7a-dimethyl-3a,4,5,6,7,7a-hexahydro-1H-indene
There total 6 articles about (3aS,7aR)-3-[(S)-1-((S)-Benzenesulfinyl)-ethyl]-7-methoxy-3a,7a-dimethyl-3a,4,5,6,7,7a-hexahydro-1H-indene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 74 mg / cerrous chloride heptahydrate, sodium borohydride / methanol / 0.08 h
2: 1.) n-BuLi; 2.) tetramethylethylenediamine (TMEDA) / 1.) THF, hexane, -78 deg C, 15 min; 2.) -45 deg C, 1 h
3: isomerization
4: 1.) lithium diethylamide; 2.) TMEDA, / 1.) THF, -78 deg C -> -45 deg C; 2.) -78 deg C -> -45 deg C, 2 h
With
sodium tetrahydroborate; n-butyllithium; cerium(III) chloride; N,N,N,N,-tetramethylethylenediamine; lithium diethylamide;
In
methanol;
DOI:10.1016/S0040-4020(01)85880-4
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 90 percent t-butyl hydroperoxide, selenium oxide / CH2Cl2 / 22 h / 15 °C
2: 74 mg / cerrous chloride heptahydrate, sodium borohydride / methanol / 0.08 h
3: 1.) n-BuLi; 2.) tetramethylethylenediamine (TMEDA) / 1.) THF, hexane, -78 deg C, 15 min; 2.) -45 deg C, 1 h
4: isomerization
5: 1.) lithium diethylamide; 2.) TMEDA, / 1.) THF, -78 deg C -> -45 deg C; 2.) -78 deg C -> -45 deg C, 2 h
With
tert.-butylhydroperoxide; sodium tetrahydroborate; n-butyllithium; selenium(IV) oxide; cerium(III) chloride; N,N,N,N,-tetramethylethylenediamine; lithium diethylamide;
In
methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)85880-4
- Guidance literature:
-
Multi-step reaction with 6 steps
2: 90 percent t-butyl hydroperoxide, selenium oxide / CH2Cl2 / 22 h / 15 °C
3: 74 mg / cerrous chloride heptahydrate, sodium borohydride / methanol / 0.08 h
4: 1.) n-BuLi; 2.) tetramethylethylenediamine (TMEDA) / 1.) THF, hexane, -78 deg C, 15 min; 2.) -45 deg C, 1 h
5: isomerization
6: 1.) lithium diethylamide; 2.) TMEDA, / 1.) THF, -78 deg C -> -45 deg C; 2.) -78 deg C -> -45 deg C, 2 h
With
tert.-butylhydroperoxide; sodium tetrahydroborate; n-butyllithium; selenium(IV) oxide; cerium(III) chloride; N,N,N,N,-tetramethylethylenediamine; lithium diethylamide;
In
methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)85880-4
