Technology Process of 4-nitro-benzoic acid 1-methyl-2-[1-(toluene-4-sulfonyl)-piperidin-2-yl]-ethyl ester
There total 11 articles about 4-nitro-benzoic acid 1-methyl-2-[1-(toluene-4-sulfonyl)-piperidin-2-yl]-ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 24h;
DOI:10.1016/j.tetlet.2007.01.082
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: imidazole / tetrahydrofuran / 8 h / 0 - 20 °C
2.1: tetrahydrofuran; diethyl ether / 6 h / -78 - 20 °C
3.1: BH3*DMS / tetrahydrofuran / 8 h / -10 - 20 °C
3.2: H2O2; NaOH / 2 h / 0 - 20 °C
4.1: diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 8 h / 0 - 20 °C
5.1: TBAF / tetrahydrofuran / 6 h / 20 °C
6.1: 95 percent / (COCl)2; DMSO; Et3N / 8 h / -78 - 20 °C
7.1: 30 percent / tetrahydrofuran; diethyl ether / 6 h / -78 - 20 °C
8.1: diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h / 0 - 20 °C
With
1H-imidazole; oxalyl dichloride; di-isopropyl azodicarboxylate; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; triphenylphosphine;
In
tetrahydrofuran; diethyl ether;
4.1: Mitsunobu condensation;
DOI:10.1016/j.tetlet.2007.01.082
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 1,1'-(azodicarbonyl)dipiperidine; n-Bu3P / toluene / 16 h / 0 - 20 °C
2.1: imidazole / tetrahydrofuran / 8 h / 0 - 20 °C
3.1: tetrahydrofuran; diethyl ether / 6 h / -78 - 20 °C
4.1: BH3*DMS / tetrahydrofuran / 8 h / -10 - 20 °C
4.2: H2O2; NaOH / 2 h / 0 - 20 °C
5.1: diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 8 h / 0 - 20 °C
6.1: TBAF / tetrahydrofuran / 6 h / 20 °C
7.1: 95 percent / (COCl)2; DMSO; Et3N / 8 h / -78 - 20 °C
8.1: 30 percent / tetrahydrofuran; diethyl ether / 6 h / -78 - 20 °C
9.1: diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h / 0 - 20 °C
With
1H-imidazole; oxalyl dichloride; tributylphosphine; di-isopropyl azodicarboxylate; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine;
In
tetrahydrofuran; diethyl ether; toluene;
1.1: Mitsunobu condensation / 5.1: Mitsunobu condensation;
DOI:10.1016/j.tetlet.2007.01.082
![(+)-(2S)-3-[(2S)-N-(p-toluenesulfonyl)piperidin-2-yl]propan-2-ol](/Databaselist/images/loading.webp)
