ABT-963

Base Information

• Chemical Name: ABT-963
• CAS No.: 468072-82-4
• Molecular Formula: C₂₂H₂₂F₂N₂O₄S
• Molecular Weight: 448.49
• Mol file: 468072-82-4.mol

Synonyms:

Chemical Property of ABT-963

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ABT-963

There total 6 articles about ABT-963 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3,4-difluorophenyl)-4-(3-hydroxy-3-methylbutoxy)-5-(4-methylsulfanylphenyl)-2H-pyridazin-3-one → ABT-963 (468072-82-4)

Guidance literature:

With Oxone; water; In acetone; at 5 - 12 ℃; for 1h; Inert atmosphere; Large scale;

DOI:10.1021/op060016v

Reference yield:

3,4-difluorophenyl hydrazine (161886-22-2) → ABT-963 (468072-82-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: water / Inert atmosphere; Reflux

2.1: sodium hexamethyldisilazane / tetrahydrofuran / -20 °C / Large scale

2.2: -20 °C / Large scale

3.1: palladium diacetate; triphenylphosphine; potassium phosphate; dipotassium hydrogen phosphate / 3.5 h / 70 - 75 °C / Inert atmosphere

4.1: Oxone; water / acetone / 1 h / 5 - 12 °C / Inert atmosphere; Large scale

With Oxone; potassium phosphate; dipotassium hydrogen phosphate; water; palladium diacetate; sodium hexamethyldisilazane; triphenylphosphine; In tetrahydrofuran; water; acetone; 3.1: |Suzuki Coupling;

DOI:10.1021/op060016v

Reference yield:

4,5-dibromo-2-(3,4-difluorophenyl)-2H-pyridazin-3-one (221031-08-9) → ABT-963 (468072-82-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / -20 °C / Large scale

1.2: -20 °C / Large scale

2.1: palladium diacetate; triphenylphosphine; potassium phosphate; dipotassium hydrogen phosphate / 3.5 h / 70 - 75 °C / Inert atmosphere

3.1: Oxone; water / acetone / 1 h / 5 - 12 °C / Inert atmosphere; Large scale

With Oxone; potassium phosphate; dipotassium hydrogen phosphate; water; palladium diacetate; sodium hexamethyldisilazane; triphenylphosphine; In tetrahydrofuran; acetone; 2.1: |Suzuki Coupling;

DOI:10.1021/op060016v

upstream raw materials:

3,4-difluorophenyl hydrazine

3,4-difluoroaniline

4,5-dibromo-2-(3,4-difluorophenyl)-2H-pyridazin-3-one

(4-thiomethoxyphenyl)boronic acid

Refernces