2-[3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

Base Information

Chemical Name:2-[3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
CAS No.:1575596-29-0
Molecular Formula:C₃₆H₄₀FN₉O₃
Molecular Weight:665.771
Hs Code.:

2-[3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

Synonyms:

Suppliers and Price of 2-[3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
PRN1008 >98%
250 mg
$ 1500.00

DC Chemicals
PRN1008 >98%
1 g
$ 3000.00

ChemScene
PRN1008 99.49%
100mg
$ 2100.00

ChemScene
PRN1008 99.49%
50mg
$ 1500.00

ChemScene
PRN1008 99.49%
25mg
$ 1100.00

ChemScene
PRN1008 99.49%
10mg
$ 550.00

ChemScene
PRN1008 99.49%
5mg
$ 350.00

Total 8 raw suppliers

Chemical Property of 2-[3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

Chemical Property:

Boiling Point:882.5±65.0 °C(Predicted)
Density:1.39±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

PRN1008 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

There total 11 articles about 2-[3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1414356-84-5
3-[(3R)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-oxopropanenitrile

: 1575591-71-7
2-methyl-2-[4-(oxetan-3-yl)piperazin-1-yl]propanal

: 1575596-29-0
2-[3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

Guidance literature:: With pyrrolidine; chloro-trimethyl-silane; In dichloromethane; at 0 - 5 ℃; for 0.5 - 1h; Large scale;

Reference yield:

: 1414356-84-5
3-[(3R)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-oxopropanenitrile

: 1575591-71-7
2-methyl-2-[4-(oxetan-3-yl)piperazin-1-yl]propanal

: 1575591-66-0,1575596-29-0
(R)-2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-methyl-4-(4-(oxetan-3-yl)piperazin-1-yl)pent-2-enenitrile

Guidance literature:: With pyrrolidine; chloro-trimethyl-silane; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 1138557-58-0
1-bromo-2-fluoro-4-phenoxybenzene

: 1575591-66-0,1575596-29-0
(R)-2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-methyl-4-(4-(oxetan-3-yl)piperazin-1-yl)pent-2-enenitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -80 - -70 °C / Inert atmosphere

1.2: 2 h / -80 - -70 °C / Inert atmosphere

2.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 4 h / 20 °C

5.1: pyrrolidine; chloro-trimethyl-silane / dichloromethane / 1 h / 0 °C

With pyrrolidine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; n-butyllithium; chloro-trimethyl-silane; potassium carbonate; triethylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;