2-methyl-2-(4-oxetan-3-yl-piperazin-1-yl)-propionaldehyde

Base Information

• Chemical Name: 2-methyl-2-(4-oxetan-3-yl-piperazin-1-yl)-propionaldehyde
• CAS No.: 1575591-71-7
• Molecular Formula: C₁₁H₂₀N₂O₂
• Molecular Weight: 212.292
• Mol file: 1575591-71-7.mol

Synonyms:2-methyl-2-(4-oxetan-3-yl-piperazin-1-yl)-propionaldehyde;2-Methyl-2-(4-(oxetan-3-yl)piperazin-1-yl)propanal

Chemical Property of 2-methyl-2-(4-oxetan-3-yl-piperazin-1-yl)-propionaldehyde

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

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Technology Process of 2-methyl-2-(4-oxetan-3-yl-piperazin-1-yl)-propionaldehyde

There total 1 articles about 2-methyl-2-(4-oxetan-3-yl-piperazin-1-yl)-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-2-methylpropanal (13206-46-7) + 1-(oxetan-3-yl)-piperazine (1254115-23-5) → 2-methyl-2-[4-(oxetan-3-yl)piperazin-1-yl]propanal (1575591-71-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield: 86.0%

3-[(3R)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-oxopropanenitrile (1414356-84-5) + 2-methyl-2-[4-(oxetan-3-yl)piperazin-1-yl]propanal (1575591-71-7) → 2-[3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (1575596-29-0)

Guidance literature:

With pyrrolidine; chloro-trimethyl-silane; In dichloromethane; at 0 - 5 ℃; for 0.5 - 1h; Large scale;

Reference yield: 74.0%

2-methyl-2-[4-(oxetan-3-yl)piperazin-1-yl]propanal (1575591-71-7) + (3S)-1-(2-cyanoacetyl)piperidin-3-yl N-[(1R)-2-phenyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.0^[2,6]]decan-4-yl]ethyl]carbamate → (3S)-1-(2-cyano-2-[2-methyl-2-[4-(oxetan-3-yl)piperazin-1-yl]propylidene]acetyl)piperidin-3-yl N-[(1R)-2-phenyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.0^[2,6]]decan-4-yl]ethyl]carbamate

Guidance literature:

With pyrrolidine; chloro-trimethyl-silane; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

2-bromo-2-methylpropanal

1-(oxetan-3-yl)-piperazine

Downstream raw materials:

(R)-2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-methyl-4-(4-(oxetan-3-yl)piperazin-1-yl)pent-2-enenitrile

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