N-Trityl-L-methionin-N'-methylhydroxylamid

Base Information

• Chemical Name: N-Trityl-L-methionin-N'-methylhydroxylamid
• CAS No.: 116887-95-7
• Molecular Formula: C₂₅H₂₈N₂O₂S
• Molecular Weight: 420.576
• Mol file: 116887-95-7.mol

Synonyms:

Chemical Property of N-Trityl-L-methionin-N'-methylhydroxylamid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Trityl-L-methionin-N'-methylhydroxylamid

There total 2 articles about N-Trityl-L-methionin-N'-methylhydroxylamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Trityl-L-Methionin-(1-hydroxybenzotriazolylester) (93984-97-5) → N-Trityl-L-methionin-N'-methylhydroxylamid (116887-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / 1.) 0 deg C, 5 min; 2.) 20 min, 0 deg C to room temp.

2: potassium-tert-butoxide / tetrahydrofuran / 1.) 5 min, -10 deg C to r.t.; 15 min; 2.) r.t., 30 min

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

N-Trityl-L-Methioninhydroxylamid (116887-93-5) + methyl iodide (74-88-4) → N-Trityl-L-methionin-N'-methylhydroxylamid (116887-95-7)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; Yield given; 1.) 5 min, -10 deg C to r.t.; 15 min; 2.) r.t., 30 min;

Reference yield:

N-Trityl-L-methionin-N'-methylhydroxylamid (116887-95-7) + methyl iodide (74-88-4) → [3-(Hydroxy-methyl-carbamoyl)-3-(trityl-amino)-propyl]-dimethyl-sulfonium; iodide (116864-52-9)

Guidance literature:

In ethyl acetate; for 24h; Ambient temperature;

upstream raw materials:

N-Trityl-L-Methioninhydroxylamid

methyl iodide

N-Trityl-L-Methionin-(1-hydroxybenzotriazolylester)

Downstream raw materials:

[3-(Hydroxy-methyl-carbamoyl)-3-(trityl-amino)-propyl]-dimethyl-sulfonium; iodide