(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-5-amino-pentyl)-phosphonic acid diphenyl ester; hydrochloride

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Chemical Name:(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-5-amino-pentyl)-phosphonic acid diphenyl ester; hydrochloride
CAS No.:146548-71-2
Molecular Formula:C₃₃H₄₁N₄O₆P*ClH
Molecular Weight:657.146
Hs Code.:

(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-5-amino-pentyl)-phosphonic acid diphenyl ester; hydrochloride

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Chemical Property of (1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-5-amino-pentyl)-phosphonic acid diphenyl ester; hydrochloride

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Technology Process of (1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-5-amino-pentyl)-phosphonic acid diphenyl ester; hydrochloride

There total 6 articles about (1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-5-amino-pentyl)-phosphonic acid diphenyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: [1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-phosphonic acid diphenyl ester

: 146548-71-2,146610-37-9
(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-5-amino-pentyl)-phosphonic acid diphenyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; hydrazine hydrate; In methanol; at 80 ℃;
DOI:10.1016/0040-4039(93)88011-7

Reference yield:

: 101-02-0
triphenyl phosphite

: 146548-71-2,146610-37-9
(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-5-amino-pentyl)-phosphonic acid diphenyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

2: i-BuOC(=O)Cl, 4-methylmorpholine, Et₃N / tetrahydrofuran / Ambient temperature

3: 57 percent / 1) H₂NNH₂*H₂O, 2) 10percent HCl / methanol / 80 °C

With 4-methyl-morpholine; hydrogenchloride; hydrazine hydrate; triethylamine; isobutyl chloroformate; In tetrahydrofuran; methanol;
DOI:10.1016/0040-4039(93)88011-7

Reference yield:

: 2508-29-4
5-hydroxypentylamine

: 146548-71-2,146610-37-9
(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-5-amino-pentyl)-phosphonic acid diphenyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / toluene / Heating

2: (COCl)2, DMSO / CH₂Cl₂ / -78 °C

4: i-BuOC(=O)Cl, 4-methylmorpholine, Et₃N / tetrahydrofuran / Ambient temperature

5: 57 percent / 1) H₂NNH₂*H₂O, 2) 10percent HCl / methanol / 80 °C

With 4-methyl-morpholine; hydrogenchloride; oxalyl dichloride; hydrazine hydrate; dimethyl sulfoxide; triethylamine; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1016/0040-4039(93)88011-7