2-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-4-oxo-4-phenyl-butyric acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide

Base Information

• Chemical Name: 2-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-4-oxo-4-phenyl-butyric acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide
• CAS No.: 77811-69-9
• Molecular Formula: C₂₅H₂₂N₂O₄
• Molecular Weight: 414.461
• Mol file: 77811-69-9.mol

Synonyms:

Chemical Property of 2-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-4-oxo-4-phenyl-butyric acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-4-oxo-4-phenyl-butyric acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide

There total 3 articles about 2-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-4-oxo-4-phenyl-butyric acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-benzylidene-4-(4-methoxyphenyl)-4-oxobutanehydrazide (57999-73-2) + salicylaldehyde (90-02-8) → 2-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-4-oxo-4-phenyl-butyric acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide (77811-69-9)

Guidance literature:

In ethanol; for 1.5h;

Reference yield:

3-(4-methoxy-benzylidene)-5-phenyl-3H-furan-2-one (13294-96-7) → 2-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-4-oxo-4-phenyl-butyric acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide (77811-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / 80percent hydrazine hydrate / Ambient temperature

2: 85 percent / ethanol / 1.5 h

With hydrazine hydrate; In ethanol;

Reference yield:

α-phenacyl-p-methoxycinnamic acid (57999-79-8) → 2-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-4-oxo-4-phenyl-butyric acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide (77811-69-9)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic anhydride, anhydreous sodium acetate / Heating

2: 85 percent / 80percent hydrazine hydrate / Ambient temperature

3: 85 percent / ethanol / 1.5 h

With sodium acetate; acetic anhydride; hydrazine hydrate; In ethanol;

upstream raw materials:

2-benzylidene-4-(4-methoxyphenyl)-4-oxobutanehydrazide

salicylaldehyde

3-(4-methoxy-benzylidene)-5-phenyl-3H-furan-2-one

α-phenacyl-p-methoxycinnamic acid