2-((S)-1-{[2-((R)-1-{[2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carbonyl]-amino}-ethyl)-5-methyl-oxazole-4-carboxylic acid pentafluorophenyl ester

Base Information

Chemical Name:2-((S)-1-{[2-((R)-1-{[2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carbonyl]-amino}-ethyl)-5-methyl-oxazole-4-carboxylic acid pentafluorophenyl ester
CAS No.:186453-48-5
Molecular Formula:C₃₁H₃₁F₅N₆O₇S₂
Molecular Weight:758.747
Hs Code.:

2-((S)-1-{[2-((R)-1-{[2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carbonyl]-amino}-ethyl)-5-methyl-oxazole-4-carboxylic acid pentafluorophenyl ester

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Chemical Property of 2-((S)-1-{[2-((R)-1-{[2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carbonyl]-amino}-ethyl)-5-methyl-oxazole-4-carboxylic acid pentafluorophenyl ester

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Technology Process of 2-((S)-1-{[2-((R)-1-{[2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carbonyl]-amino}-ethyl)-5-methyl-oxazole-4-carboxylic acid pentafluorophenyl ester

There total 20 articles about 2-((S)-1-{[2-((R)-1-{[2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carbonyl]-amino}-ethyl)-5-methyl-oxazole-4-carboxylic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 182866-72-4
1'(S)-2-(1-benzyloxycarbonylaminoethyl)-5-methyloxazole-4-carboxylic acid methyl ester

: 186453-48-5
2-((S)-1-{[2-((R)-1-{[2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carbonyl]-amino}-ethyl)-5-methyl-oxazole-4-carboxylic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / H₂ / 10percent Pd/C / methanol / 4 h / 760 Torr / Ambient temperature

2: tetrahydrofuran / 1 h / 0 °C

3: 100 percent / AcCl, MeOH / 2 h / Ambient temperature

4: tetrahydrofuran / 0.75 h

5: 93 percent / aq. LiOH / methanol / Ambient temperature

6: EDCI / CH₂Cl₂ / 16 h / -10 - 20 °C

With methanol; lithium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetyl chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 204378-74-5
2-((S)-1-{[2-((R)-1-{[2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carbonyl]-amino}-ethyl)-5-methyl-oxazole-4-carboxylic acid

: 186453-48-5
2-((S)-1-{[2-((R)-1-{[2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carbonyl]-amino}-ethyl)-5-methyl-oxazole-4-carboxylic acid pentafluorophenyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at -10 - 20 ℃; for 16h; Yield given;

Reference yield:

: 4530-20-5
BOC-glycine

: 186453-48-5
2-((S)-1-{[2-((R)-1-{[2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carbonyl]-amino}-ethyl)-5-methyl-oxazole-4-carboxylic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: Et₃N / tetrahydrofuran / 0.42 h / -10 °C

2: aq. MH₃ / tetrahydrofuran / 0.75 h / -10 °C

3: 85 percent / Lawesson's reagent / CH₂Cl₂ / 16 h / Ambient temperature

4: KHCO₃ / 1,2-dimethoxy-ethane / 16 h / -15 °C

5: TFAA, 2,6-lutidine / 1,2-dimethoxy-ethane / 0.5 h / -10 °C

6: 87 percent / aq. LiOH / methanol / 3 h / Ambient temperature

7: N-methylmorpholine / tetrahydrofuran / 0.5 h / 0 °C

8: tetrahydrofuran / 0.75 h

9: 93 percent / aq. LiOH / methanol / Ambient temperature

10: EDCI / CH₂Cl₂ / 16 h / -10 - 20 °C

With Lawessons reagent; 4-methyl-morpholine; 2,6-dimethylpyridine; lithium hydroxide; ammonium hydroxide; potassium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane;