6-(N,N-dimethylamino)-N-[2-(phosphoryloxy)-ethyl]hexanoic acid p-nitrophenyl ester

Base Information

• Chemical Name: 6-(N,N-dimethylamino)-N-[2-(phosphoryloxy)-ethyl]hexanoic acid p-nitrophenyl ester
• CAS No.: 952212-15-6
• Molecular Formula: C₁₆H₂₅N₂O₈P
• Molecular Weight: 404.357
• Mol file: 952212-15-6.mol

Synonyms:

Chemical Property of 6-(N,N-dimethylamino)-N-[2-(phosphoryloxy)-ethyl]hexanoic acid p-nitrophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(N,N-dimethylamino)-N-[2-(phosphoryloxy)-ethyl]hexanoic acid p-nitrophenyl ester

There total 7 articles about 6-(N,N-dimethylamino)-N-[2-(phosphoryloxy)-ethyl]hexanoic acid p-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(N,N-dimethylamino)hexanoic acid methyl ester hydrochloride (952212-09-8) → 6-(N,N-dimethylamino)-N-[2-(phosphoryloxy)-ethyl]hexanoic acid p-nitrophenyl ester (952212-15-6)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium carbonate / acetonitrile / 70 °C

2: lithium hydroxide / water; butan-1-ol / 20 °C / Heating

3: pyridine; diisopropyl-carbodiimide / 27 h / 20 °C

4: formic acid / water / 1 h / 20 °C

5: 1H-imidazole; trichlorophosphate / acetonitrile / 1 h / Cooling with ice

With pyridine; 1H-imidazole; formic acid; sodium carbonate; lithium hydroxide; diisopropyl-carbodiimide; trichlorophosphate; In water; acetonitrile; butan-1-ol;

DOI:10.1002/anie.201005059

Reference yield:

6-(N,N-dimethylamino)-N-[2-(trityloxy)-ethyl]hexanoic acid methyl ester → 6-(N,N-dimethylamino)-N-[2-(phosphoryloxy)-ethyl]hexanoic acid p-nitrophenyl ester (952212-15-6)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium hydroxide / water; butan-1-ol / 20 °C / Heating

2: pyridine; diisopropyl-carbodiimide / 27 h / 20 °C

3: formic acid / water / 1 h / 20 °C

4: 1H-imidazole; trichlorophosphate / acetonitrile / 1 h / Cooling with ice

With pyridine; 1H-imidazole; formic acid; lithium hydroxide; diisopropyl-carbodiimide; trichlorophosphate; In water; acetonitrile; butan-1-ol;

DOI:10.1002/anie.201005059

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → 6-(N,N-dimethylamino)-N-[2-(phosphoryloxy)-ethyl]hexanoic acid p-nitrophenyl ester (952212-15-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine; diisopropyl-carbodiimide / 27 h / 20 °C

2: formic acid / water / 1 h / 20 °C

3: 1H-imidazole; trichlorophosphate / acetonitrile / 1 h / Cooling with ice

With pyridine; 1H-imidazole; formic acid; diisopropyl-carbodiimide; trichlorophosphate; In water; acetonitrile;

DOI:10.1002/anie.201005059

upstream raw materials:

6-(N,N-dimethylamino)hexanoic acid methyl ester hydrochloride

4-nitro-phenol

N,N-dimethyl-ε-aminohexanoic acid