[4-(7-Chloroquinolin-4-yl)piperazin-1-yl](4-fluorophenyl)methanone

Base Information

Chemical Name:[4-(7-Chloroquinolin-4-yl)piperazin-1-yl](4-fluorophenyl)methanone
CAS No.:774551-32-5
Molecular Formula:C₂₀H₁₇ClFN₃O
Molecular Weight:369.826
Hs Code.:
DSSTox Substance ID:DTXSID201164629
ChEMBL ID:CHEMBL1822267

Synonyms:CHEMBL1822267;DTXSID201164629;STK206028;AKOS000424805;CCG-290104;SR-01000300537;SR-01000300537-1;BRD-K14695270-001-01-7;[4-(7-Chloro-4-quinolinyl)-1-piperazinyl](4-fluorophenyl)methanone;[4-(7-chloroquinolin-4-yl)piperazin-1-yl](4-fluorophenyl)methanone;774551-32-5

Suppliers and Price of [4-(7-Chloroquinolin-4-yl)piperazin-1-yl](4-fluorophenyl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of [4-(7-Chloroquinolin-4-yl)piperazin-1-yl](4-fluorophenyl)methanone

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:369.1044180
Heavy Atom Count:26
Complexity:491

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1C2=C3C=CC(=CC3=NC=C2)Cl)C(=O)C4=CC=C(C=C4)F

Technology Process of [4-(7-Chloroquinolin-4-yl)piperazin-1-yl](4-fluorophenyl)methanone

There total 2 articles about [4-(7-Chloroquinolin-4-yl)piperazin-1-yl](4-fluorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 774551-32-5
C₂₀H₁₇ClFN₃O

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 4 h / 130 °C / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2011.06.105

Reference yield:

: 456-22-4
4-Fluorobenzoic acid

: 837-52-5
7-chloro-4-piperazinylquinoline

: 774551-32-5
C₂₀H₁₇ClFN₃O

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.bmcl.2011.06.105