2,2-dimethylpropionic acid [(1S,4R)-2-(tert-butyldimethylsilanyloxymethyl)-4-(4'-methoxybenzyloxy)-3-[5-(2'-methoxyethoxymethoxy)pentyl]cyclopent-2-enyl]methyl ester

Base Information

Chemical Name:2,2-dimethylpropionic acid [(1S,4R)-2-(tert-butyldimethylsilanyloxymethyl)-4-(4'-methoxybenzyloxy)-3-[5-(2'-methoxyethoxymethoxy)pentyl]cyclopent-2-enyl]methyl ester
CAS No.:896110-35-3
Molecular Formula:C₃₅H₆₀O₈Si
Molecular Weight:636.942
Hs Code.:

2,2-dimethylpropionic acid [(1S,4R)-2-(tert-butyldimethylsilanyloxymethyl)-4-(4'-methoxybenzyloxy)-3-[5-(2'-methoxyethoxymethoxy)pentyl]cyclopent-2-enyl]methyl ester

Synonyms:

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Chemical Property of 2,2-dimethylpropionic acid [(1S,4R)-2-(tert-butyldimethylsilanyloxymethyl)-4-(4'-methoxybenzyloxy)-3-[5-(2'-methoxyethoxymethoxy)pentyl]cyclopent-2-enyl]methyl ester

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Technology Process of 2,2-dimethylpropionic acid [(1S,4R)-2-(tert-butyldimethylsilanyloxymethyl)-4-(4'-methoxybenzyloxy)-3-[5-(2'-methoxyethoxymethoxy)pentyl]cyclopent-2-enyl]methyl ester

There total 9 articles about 2,2-dimethylpropionic acid [(1S,4R)-2-(tert-butyldimethylsilanyloxymethyl)-4-(4'-methoxybenzyloxy)-3-[5-(2'-methoxyethoxymethoxy)pentyl]cyclopent-2-enyl]methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 896110-62-6
2,2-Dimethyl-propionic acid (1S,4R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(5-hydroxy-pentyl)-4-(4-methoxy-benzyloxy)-cyclopent-2-enylmethyl ester

: 3970-21-6
2-Methoxyethoxymethyl chloride

: 896110-35-3
2,2-dimethylpropionic acid [(1S,4R)-2-(tert-butyldimethylsilanyloxymethyl)-4-(4'-methoxybenzyloxy)-3-[5-(2'-methoxyethoxymethoxy)pentyl]cyclopent-2-enyl]methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tet.2005.11.096

Reference yield:

: 896110-29-5
benzoic acid 5-[(R)-4'-(2'',2''-dimethylpropionyloxymethyl)-6'-oxocyclohex-1'-enyl]pentyl ester

: 896110-35-3
2,2-dimethylpropionic acid [(1S,4R)-2-(tert-butyldimethylsilanyloxymethyl)-4-(4'-methoxybenzyloxy)-3-[5-(2'-methoxyethoxymethoxy)pentyl]cyclopent-2-enyl]methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: CeCl₃*7H₂O; NaBH₄ / methanol / 1 h / 0 °C

2.1: TfOH / diethyl ether / 0 - 20 °C

3.1: ozone / CH₂Cl₂; methanol / -78 °C

3.2: PPh₃ / CH₂Cl₂; methanol / -78 - 20 °C

4.1: piperidine; acetic acid / diethyl ether / 20 h / Heating

5.1: NaBH₄ / methanol / 0.33 h / 0 °C

6.1: imidazole / CH₂Cl₂ / 1 h / 20 °C

7.1: K₂CO₃ / methanol / 20 °C

8.1: ethyldiisopropylamine / CH₂Cl₂ / 0 - 20 °C

With piperidine; 1H-imidazole; sodium tetrahydroborate; cerium(III) chloride; trifluorormethanesulfonic acid; potassium carbonate; ozone; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane; 1.1: Luche reaction;
DOI:10.1016/j.tet.2005.11.096

Reference yield:

: Benzoic acid 5-[(R)-4-(2,2-dimethyl-propionyloxymethyl)-6-hydroxy-cyclohex-1-enyl]-pentyl ester

: 896110-35-3
2,2-dimethylpropionic acid [(1S,4R)-2-(tert-butyldimethylsilanyloxymethyl)-4-(4'-methoxybenzyloxy)-3-[5-(2'-methoxyethoxymethoxy)pentyl]cyclopent-2-enyl]methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: TfOH / diethyl ether / 0 - 20 °C

2.1: ozone / CH₂Cl₂; methanol / -78 °C

2.2: PPh₃ / CH₂Cl₂; methanol / -78 - 20 °C

3.1: piperidine; acetic acid / diethyl ether / 20 h / Heating

4.1: NaBH₄ / methanol / 0.33 h / 0 °C

5.1: imidazole / CH₂Cl₂ / 1 h / 20 °C

6.1: K₂CO₃ / methanol / 20 °C

7.1: ethyldiisopropylamine / CH₂Cl₂ / 0 - 20 °C

With piperidine; 1H-imidazole; sodium tetrahydroborate; trifluorormethanesulfonic acid; potassium carbonate; ozone; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane;
DOI:10.1016/j.tet.2005.11.096