[(1-Benzyl-7-cyano-1H-indole-2-carbonyl)-(1-diethoxymethyl-2-methyl-propyl)-amino]-acetic acid ethyl ester

Base Information

Chemical Name:[(1-Benzyl-7-cyano-1H-indole-2-carbonyl)-(1-diethoxymethyl-2-methyl-propyl)-amino]-acetic acid ethyl ester
CAS No.:1027295-01-7
Molecular Formula:C₃₀H₃₇N₃O₅
Molecular Weight:519.641
Hs Code.:

Synonyms:

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Chemical Property of [(1-Benzyl-7-cyano-1H-indole-2-carbonyl)-(1-diethoxymethyl-2-methyl-propyl)-amino]-acetic acid ethyl ester

Chemical Property:

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Technology Process of [(1-Benzyl-7-cyano-1H-indole-2-carbonyl)-(1-diethoxymethyl-2-methyl-propyl)-amino]-acetic acid ethyl ester

There total 28 articles about [(1-Benzyl-7-cyano-1H-indole-2-carbonyl)-(1-diethoxymethyl-2-methyl-propyl)-amino]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: valinal diethyl acetal

: 1027295-01-7
[(1-Benzyl-7-cyano-1H-indole-2-carbonyl)-(1-diethoxymethyl-2-methyl-propyl)-amino]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / triethylamine / tetrahydrofuran / 40 h

2: triethylamine / CH₂Cl₂

With triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00001a014

Reference yield:

: 1-Benzyl-7-formyl-1H-indole-2-carboxylic acid

: 1027295-01-7
[(1-Benzyl-7-cyano-1H-indole-2-carbonyl)-(1-diethoxymethyl-2-methyl-propyl)-amino]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: oxalyl chloride, N,N-dimethylformamide / CH₂Cl₂ / 1 h

2: triethylamine / CH₂Cl₂

3: conc. sulfuric acid / diethyl ether / 3 h

4: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) THF, H₂O, overnight, 2.) ethanol, H₂O, 2 h

5: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s); H₂O / 0.5 h

6: 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide

7: nitromethane, aluminum chloride / benzene / 1 h

8: sodium chlorite, sodium dihydrogen phosphate / 2-methyl-propan-2-ol; tetrahydrofuran; various solvent(s); H₂O / 0.5 h

9: 48 percent / methanol; diethyl ether

10: 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide, dichloroacetic acid / dimethylsulfoxide; toluene / 2 h / Ambient temperature

11: lithium hydroxide / tetrahydrofuran; methanol; H₂O / 1 h

12: oxalyl chloride, N,N-dimethylformamide / CH₂Cl₂ / 1 h

13: triethylamine / CH₂Cl₂

With dichloro-acetic acid; lithium hydroxide; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; aluminium trichloride; sodium dihydrogen phosphate; oxalyl dichloride; nitromethane; sulfuric acid; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4-methylmorpholine N-oxide; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; benzene;
DOI:10.1021/jm00001a014

Reference yield:

: 1-Benzyl-7-formyl-1H-indole-2-carbonyl chloride

: 1027295-01-7
[(1-Benzyl-7-cyano-1H-indole-2-carbonyl)-(1-diethoxymethyl-2-methyl-propyl)-amino]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: triethylamine / CH₂Cl₂

2: conc. sulfuric acid / diethyl ether / 3 h

3: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) THF, H₂O, overnight, 2.) ethanol, H₂O, 2 h

4: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s); H₂O / 0.5 h

5: 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide

6: nitromethane, aluminum chloride / benzene / 1 h

7: sodium chlorite, sodium dihydrogen phosphate / 2-methyl-propan-2-ol; tetrahydrofuran; various solvent(s); H₂O / 0.5 h

8: 48 percent / methanol; diethyl ether

9: 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide, dichloroacetic acid / dimethylsulfoxide; toluene / 2 h / Ambient temperature

10: lithium hydroxide / tetrahydrofuran; methanol; H₂O / 1 h

11: oxalyl chloride, N,N-dimethylformamide / CH₂Cl₂ / 1 h

12: triethylamine / CH₂Cl₂

With dichloro-acetic acid; lithium hydroxide; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; aluminium trichloride; sodium dihydrogen phosphate; oxalyl dichloride; nitromethane; sulfuric acid; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4-methylmorpholine N-oxide; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; benzene;
DOI:10.1021/jm00001a014