diisopropyl-phosphoramidous acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Chemical Name:diisopropyl-phosphoramidous acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
CAS No.:908141-04-8
Molecular Formula:C₅₂H₆₃ClN₅O₁₀P
Molecular Weight:984.526
Hs Code.:

diisopropyl-phosphoramidous acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5-(2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Chemical Property of diisopropyl-phosphoramidous acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Technology Process of diisopropyl-phosphoramidous acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

There total 8 articles about diisopropyl-phosphoramidous acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 908141-04-8
diisopropyl-phosphoramidous acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: acetonitrile / 20 °C

With pyridine; In acetonitrile;
DOI:10.1081/NCN-200060150

Reference yield:

: 58-96-8
uridine

: 908141-04-8
diisopropyl-phosphoramidous acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / acetonitrile

2: DCA / CH₂Cl₂

3: TEAF / tetrahydrofuran

4: pyridine

5: acetonitrile / 20 °C

With pyridine; dichloro-acetic acid; tetraethylammonium fluoride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1081/NCN-200060150

Reference yield:

: 263008-89-5
1-(4-Chlorophenyl)-4,4-diethoxypiperidine

: 908141-04-8
diisopropyl-phosphoramidous acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Huenig's base; BF₃*Et₂O / CH₂Cl₂ / 0 °C

2: DCA / CH₂Cl₂

3: TEAF / tetrahydrofuran

4: pyridine

5: acetonitrile / 20 °C

With pyridine; dichloro-acetic acid; boron trifluoride diethyl etherate; tetraethylammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1081/NCN-200060150