C₁₂H₁₇N₃O₂

Base Information

• Chemical Name: C₁₂H₁₇N₃O₂
• CAS No.: 1277168-04-3
• Molecular Formula: C₁₂H₁₇N₃O₂
• Molecular Weight: 235.286
• Mol file: 1277168-04-3.mol

Synonyms:

Chemical Property of C₁₂H₁₇N₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₇N₃O₂

There total 4 articles about C₁₂H₁₇N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H25N3O4 → C12H17N3O2 (1277168-04-3)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; dichloromethane; at 20 ℃; for 5h;

DOI:10.1016/j.bmcl.2011.02.033

Reference yield:

2-hydroxybromobenzene (95-56-7) → C12H17N3O2 (1277168-04-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 18-crown-6 ether; potassium carbonate / acetonitrile / 20 h / Reflux

2: palladium diacetate; caesium carbonate; XPhos / 1,4-dioxane / 20 h / Reflux

3: 5% Pd(II)/C(eggshell); hydrogen / 2 h / 20 °C

4: 18-crown-6 ether; potassium carbonate / acetonitrile / 20 h / Reflux

5: hydrogenchloride; water / 1,4-dioxane; dichloromethane / 5 h / 20 °C

With hydrogenchloride; 18-crown-6 ether; 5% Pd(II)/C(eggshell); water; hydrogen; palladium diacetate; potassium carbonate; caesium carbonate; XPhos; In 1,4-dioxane; dichloromethane; acetonitrile; 2: Buchwald amination;

DOI:10.1016/j.bmcl.2011.02.033

Reference yield:

tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylate (313657-51-1) → C12H17N3O2 (1277168-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 18-crown-6 ether; potassium carbonate / acetonitrile / 20 h / Reflux

2: hydrogenchloride; water / 1,4-dioxane; dichloromethane / 5 h / 20 °C

With hydrogenchloride; 18-crown-6 ether; water; potassium carbonate; In 1,4-dioxane; dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2011.02.033

upstream raw materials:

2-hydroxybromobenzene

tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylate

1-tert-butoxycarbonyl-4-(2-(benzyloxy)phenyl)piperazine

Downstream raw materials:

C₂₂H₂₂ClN₅O₃