2-(2'-oxocyclopentyl)ethyl p-nitrophenyl thioether oxime O-methyl ether

Base Information

• Chemical Name: 2-(2'-oxocyclopentyl)ethyl p-nitrophenyl thioether oxime O-methyl ether
• CAS No.: 121374-45-6
• Molecular Formula: C₁₄H₁₈N₂O₃S
• Molecular Weight: 294.375
• Mol file: 121374-45-6.mol

Synonyms:

Chemical Property of 2-(2'-oxocyclopentyl)ethyl p-nitrophenyl thioether oxime O-methyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2'-oxocyclopentyl)ethyl p-nitrophenyl thioether oxime O-methyl ether

There total 1 articles about 2-(2'-oxocyclopentyl)ethyl p-nitrophenyl thioether oxime O-methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

1-(2-oxocyclopentyl)-2-<(p-nitrophenyl)thio>ethane (121374-43-4) + N-methoxylamine hydrochloride (593-56-6) → 2-(2'-oxocyclopentyl)ethyl p-nitrophenyl thioether oxime O-methyl ether (121374-44-5) + 2-(2'-oxocyclopentyl)ethyl p-nitrophenyl thioether oxime O-methyl ether (121374-45-6)

Guidance literature:

With pyridine; In ethanol; for 16h; Heating;

DOI:10.1021/jo00275a034

Reference yield:

2-(2'-oxocyclopentyl)ethyl p-nitrophenyl thioether oxime O-methyl ether (121374-44-5,121374-45-6) → cis-2-(2'-aminocyclopentyl)ethyl p-nitrophenyl thioether (121374-47-8,121375-00-6)

Guidance literature:

With sodium tetrahydroborate; trifluoroacetic acid; In tetrahydrofuran; 1.) RT, 2 h, 2.) reflux, 16 h;

DOI:10.1021/jo00275a034

Reference yield:

2-(2'-oxocyclopentyl)ethyl p-nitrophenyl thioether oxime O-methyl ether (121374-44-5,121374-45-6) → cis-2-<2'-cyclopentyl>ethyl p-nitrophenyl thioether (121374-50-3,121374-53-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium borohydride, trifluoroacetic acid / tetrahydrofuran / 1.) RT, 2 h, 2.) reflux, 16 h

2: 66 percent / 1 N NaOH / diethyl ether / 18 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; trifluoroacetic acid; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo00275a034

upstream raw materials:

1-(2-oxocyclopentyl)-2-<(p-nitrophenyl)thio>ethane

N-methoxylamine hydrochloride

Downstream raw materials:

cis-2-(2'-aminocyclopentyl)ethyl p-nitrophenyl thioether

cis-2-<2'-cyclopentyl>ethyl p-nitrophenyl thioether