1-(2-acetamido-5-acetoxy-4-methoxybenzyl)-2-carbomethoxy-6-oxo-1,2,3,4,5,6,7,8-octahydroisoquinoline

Base Information

Chemical Name:1-(2-acetamido-5-acetoxy-4-methoxybenzyl)-2-carbomethoxy-6-oxo-1,2,3,4,5,6,7,8-octahydroisoquinoline
CAS No.:78792-70-8
Molecular Formula:C₂₃H₂₈N₂O₇
Molecular Weight:444.485
Hs Code.:

Synonyms:

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Chemical Property of 1-(2-acetamido-5-acetoxy-4-methoxybenzyl)-2-carbomethoxy-6-oxo-1,2,3,4,5,6,7,8-octahydroisoquinoline

Chemical Property:

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Technology Process of 1-(2-acetamido-5-acetoxy-4-methoxybenzyl)-2-carbomethoxy-6-oxo-1,2,3,4,5,6,7,8-octahydroisoquinoline

There total 4 articles about 1-(2-acetamido-5-acetoxy-4-methoxybenzyl)-2-carbomethoxy-6-oxo-1,2,3,4,5,6,7,8-octahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14418-58-7
1-<3-O-Methoxy-carbonyl-4-methoxy-benzyl>-2-methoxycarbonyl-6-methoxy-1,2,3,4,5,8-hexahydro-isochinolin

: 78792-70-8
1-(2-acetamido-5-acetoxy-4-methoxybenzyl)-2-carbomethoxy-6-oxo-1,2,3,4,5,6,7,8-octahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 5.6 g / aq. NaOH (1N) / methanol / 2 h / 50 - 60 °C

2: 1.4 g / sulfanilic acid, monohydrate, sodium carbonate, aq.HCl (conc.),sodium hydroxide, sodium hydrosulfite / 1) 0 deg C, 30 min., water, methanol, 2) heating on the steam bath, 15 min., 3) refrigerator, overnight, pyridine

With hydrogenchloride; sodium hydroxide; sodium disulfite; sodium carbonate; 4-aminobenzene sulfonic acid; In methanol;
DOI:10.1002/jhet.5570180226

Reference yield:

: 23180-28-1
6-methoxy-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4,5,8-hexahydroisoquinoline

: 78792-70-8
1-(2-acetamido-5-acetoxy-4-methoxybenzyl)-2-carbomethoxy-6-oxo-1,2,3,4,5,6,7,8-octahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 6.4 g / NaOH (2N) / acetone; H₂O / 2 h

2: 5.6 g / aq. NaOH (1N) / methanol / 2 h / 50 - 60 °C

3: 1.4 g / sulfanilic acid, monohydrate, sodium carbonate, aq.HCl (conc.),sodium hydroxide, sodium hydrosulfite / 1) 0 deg C, 30 min., water, methanol, 2) heating on the steam bath, 15 min., 3) refrigerator, overnight, pyridine

With hydrogenchloride; sodium hydroxide; sodium disulfite; sodium carbonate; 4-aminobenzene sulfonic acid; In methanol; water; acetone;
DOI:10.1002/jhet.5570180226

Reference yield:

: 96590-43-1
6-methoxy-1-(3-benzyloxy-4-methoxybenzyl)-3,4-dihydroisoquinoline

: 78792-70-8
1-(2-acetamido-5-acetoxy-4-methoxybenzyl)-2-carbomethoxy-6-oxo-1,2,3,4,5,6,7,8-octahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / ammonia (l), lI / 4 h / -80 °C

2: 6.4 g / NaOH (2N) / acetone; H₂O / 2 h

3: 5.6 g / aq. NaOH (1N) / methanol / 2 h / 50 - 60 °C

4: 1.4 g / sulfanilic acid, monohydrate, sodium carbonate, aq.HCl (conc.),sodium hydroxide, sodium hydrosulfite / 1) 0 deg C, 30 min., water, methanol, 2) heating on the steam bath, 15 min., 3) refrigerator, overnight, pyridine

With hydrogenchloride; sodium hydroxide; sodium disulfite; ammonia; lithium; sodium carbonate; 4-aminobenzene sulfonic acid; In methanol; water; acetone;
DOI:10.1002/jhet.5570180226