6-methoxy-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4,5,8-hexahydroisoquinoline

Base Information

Chemical Name:6-methoxy-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4,5,8-hexahydroisoquinoline
CAS No.:23180-28-1
Molecular Formula:C₁₈H₂₃NO₃
Molecular Weight:301.386
Hs Code.:

Synonyms:6-methoxy-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4,5,8-hexahydroisoquinoline

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Chemical Property of 6-methoxy-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4,5,8-hexahydroisoquinoline

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Technology Process of 6-methoxy-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4,5,8-hexahydroisoquinoline

There total 4 articles about 6-methoxy-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4,5,8-hexahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 96590-43-1
6-methoxy-1-(3-benzyloxy-4-methoxybenzyl)-3,4-dihydroisoquinoline

: 23180-28-1
6-methoxy-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4,5,8-hexahydroisoquinoline

Guidance literature:: With ammonia; lithium; at -80 ℃; for 4h;
DOI:10.1002/jhet.5570180226

Reference yield: 90.0%

: 23180-27-0
1-(3'-hydroxy-4'-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: 23180-28-1
6-methoxy-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4,5,8-hexahydroisoquinoline

Guidance literature:: With ammonia; lithium; In tetrahydrofuran; tert-butyl alcohol; 1) 4h -55 to -65 deg C 2) 1.5h -75 deg C;
DOI:10.1021/jo01303a045

Reference yield:

: 74007-21-9
N-<2-(3-methoxyphenyl)ethyl>(3-hydroxy-4-methoxyphenyl)acetamide

: 23180-28-1
6-methoxy-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4,5,8-hexahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 2)Na(CN)BH₃ / 1) cyclization, neutralization to pH 4-5 with concentrated aqueous NH₃ 2) reduction with Na(CN)BH₃ in refluxing 65percent MeOH for 1.5h

2: 90 percent / Li, NH₃ (liquid) / tetrahydrofuran; 2-methyl-propan-2-ol / 1) 4h -55 to -65 deg C 2) 1.5h -75 deg C

With ammonia; lithium; sodium cyanoborohydride; In tetrahydrofuran; tert-butyl alcohol;
DOI:10.1021/jo01303a045