(1R,2R)-trans-cyclohexanediol bis<2,3,7,8-tetramethyl-(10H)-dipyrrin-1-one-9-carboxylate>

Base Information

• Chemical Name: (1R,2R)-trans-cyclohexanediol bis<2,3,7,8-tetramethyl-(10H)-dipyrrin-1-one-9-carboxylate>
• CAS No.: 135570-18-2
• Molecular Formula: C₃₄H₄₀N₄O₆
• Molecular Weight: 600.715
• Mol file: 135570-18-2.mol

Synonyms:

Chemical Property of (1R,2R)-trans-cyclohexanediol bis<2,3,7,8-tetramethyl-(10H)-dipyrrin-1-one-9-carboxylate>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-trans-cyclohexanediol bis<2,3,7,8-tetramethyl-(10H)-dipyrrin-1-one-9-carboxylate>

There total 7 articles about (1R,2R)-trans-cyclohexanediol bis<2,3,7,8-tetramethyl-(10H)-dipyrrin-1-one-9-carboxylate> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dimethyl-1H-pyrrole (822-51-5) → (1R,2R)-trans-cyclohexanediol bis<2,3,7,8-tetramethyl-(10H)-dipyrrin-1-one-9-carboxylate> (135570-18-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 59 percent / 30percent H₂O₂ / pyridine / 1) below 35 deg C, 20 min, 2) 85 deg C, 20 min

2: 54 percent / 4 N NaOH / methanol / 1 h / Heating

3: 1) 1,1'-carbonyldiimidazole, 2) DBU, molecular sieves-4 Angstroem / 1) DMSO, 40 deg C, 20 - 30 min, 2) 80 - 100 deg C, 16 - 20 h

With sodium hydroxide; 4 A molecular sieve; dihydrogen peroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole; In pyridine; methanol;

DOI:10.1021/jo00021a013

Reference yield:

3,4-dimethyl-3-pyrrolin-2-one (4030-22-2) → (1R,2R)-trans-cyclohexanediol bis<2,3,7,8-tetramethyl-(10H)-dipyrrin-1-one-9-carboxylate> (135570-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / 4 N NaOH / methanol / 1 h / Heating

2: 1) 1,1'-carbonyldiimidazole, 2) DBU, molecular sieves-4 Angstroem / 1) DMSO, 40 deg C, 20 - 30 min, 2) 80 - 100 deg C, 16 - 20 h

With sodium hydroxide; 4 A molecular sieve; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole; In methanol;

DOI:10.1021/jo00021a013

Reference yield:

3,4-dimethyl-1H-pyrrole-2-carboxylic acid (89776-55-6) → (1R,2R)-trans-cyclohexanediol bis<2,3,7,8-tetramethyl-(10H)-dipyrrin-1-one-9-carboxylate> (135570-18-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / 180 - 195 °C

2: 59 percent / 30percent H₂O₂ / pyridine / 1) below 35 deg C, 20 min, 2) 85 deg C, 20 min

3: 54 percent / 4 N NaOH / methanol / 1 h / Heating

4: 1) 1,1'-carbonyldiimidazole, 2) DBU, molecular sieves-4 Angstroem / 1) DMSO, 40 deg C, 20 - 30 min, 2) 80 - 100 deg C, 16 - 20 h

With sodium hydroxide; 4 A molecular sieve; dihydrogen peroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole; In pyridine; methanol;

DOI:10.1021/jo00021a013

upstream raw materials:

(1R,2R)-trans-1,2-cyclohexanediol

2,3,7,8-tetramethyl-(10H)-dipyrrin-1-one-9-carboxylic acid

3,4-dimethyl-1H-pyrrole

3,4-dimethyl-3-pyrrolin-2-one