2-(4-nitrophenyl)acetamide

Base Information

• Chemical Name: 2-(4-nitrophenyl)acetamide
• CAS No.: 6321-12-6
• Molecular Formula: C8H8 N2 O3
• Molecular Weight: 180.163
• Mol file: 6321-12-6.mol

Synonyms:Acetamide,2-(p-nitrophenyl)- (6CI,8CI); 2-(4-Nitrophenyl)acetamide;2-(p-Nitrophenyl)acetamide; 4-Nitrophenylacetamide; NSC 32436

Chemical Property of 2-(4-nitrophenyl)acetamide

Chemical Property:

• Vapor Pressure: 1.15E-07mmHg at 25°C
• Boiling Point: 432°C at 760 mmHg
• Flash Point: 215°C
• Density: 1.335g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-nitrophenyl)acetamide

There total 18 articles about 2-(4-nitrophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(p-nitrophenyl)ethylamine (24954-67-4) → 2-(4-nitrophenyl)acetamide (6321-12-6)

Guidance literature:

With C₃₁H₂₉Br₂N₃Ru; potassium tert-butylate; In tert-butyl alcohol; at 70 ℃; for 24h; regioselective reaction;

DOI:10.1039/d1cy01541a

Reference yield: 91.0%

4-Nitrophenylacetonitrile (555-21-5,34512-13-5,174848-08-9) → 2-(4-nitrophenyl)acetamide (6321-12-6)

Guidance literature:

With sodium azide; water; at 90 ℃; for 7h;

DOI:10.3184/174751915X14296361042516

Reference yield: 87.0%

4-nitrobenzeneacetic acid (104-03-0) → 2-(4-nitrophenyl)acetamide (6321-12-6)

Guidance literature:

4-nitrobenzeneacetic acid; With thionyl chloride; In tetrahydrofuran; at 50 ℃; for 1h;

With ammonium hydroxide; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

DOI:10.1021/acs.orglett.8b02422

upstream raw materials:

4-Nitrophenylacetonitrile

Benzeneacetamide

sulfuric acid

nitric acid

Downstream raw materials:

(4-nitro-phenyl)-acetic acid-(2,2,2-trichloro-1-hydroxy-ethylamide)

2-(4-aminophenyl)acetamide

2-(4-nitro-phenyl)-5-oxo-3,5-diphenyl-valeric acid amide

3,4-Bis-(4-nitro-phenyl)-1,5-dihydro-pyrrol-2-one

Refernces

• 1、 Yadav, Suman,Reshi, Noor U Din,Pal, Saikat,Bera, Jitendra K.. "Aerobic oxidation of primary amines to amides catalyzed by an annulated mesoionic carbene (MIC) stabilized Ru complex". . p. 7018 - 7028. Retrieved 2021/11/17.
• 2、 -. "TARGETED PEPTIDE CONJUGATES". Paragraph 0238; 0239. . Retrieved 2018/08/12.