N-((2S,3R)-2-(2-chlorophenyl)-5-oxotetrahydrofuran-3-yl)-4-nitrobenzenesulfonamide

Base Information

Chemical Name:N-((2S,3R)-2-(2-chlorophenyl)-5-oxotetrahydrofuran-3-yl)-4-nitrobenzenesulfonamide
CAS No.:1613157-27-9
Molecular Formula:C₁₆H₁₃ClN₂O₆S
Molecular Weight:396.808
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((2S,3R)-2-(2-chlorophenyl)-5-oxotetrahydrofuran-3-yl)-4-nitrobenzenesulfonamide

Chemical Property:

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Technology Process of N-((2S,3R)-2-(2-chlorophenyl)-5-oxotetrahydrofuran-3-yl)-4-nitrobenzenesulfonamide

There total 4 articles about N-((2S,3R)-2-(2-chlorophenyl)-5-oxotetrahydrofuran-3-yl)-4-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₁ClN₂O₆S

: 1613157-27-9
N-((2S,3R)-2-(2-chlorophenyl)-5-oxotetrahydrofuran-3-yl)-4-nitrobenzenesulfonamide

Guidance literature:: With silica gel; In chloroform; at 40 ℃; for 0.166667h; Inert atmosphere; Molecular sieve;
DOI:10.1039/c4cc01944j

Reference yield:

: 1255944-55-8
(E)-4-(2-chlorophenyl)but-3-enoic acid

: 1613157-27-9
N-((2S,3R)-2-(2-chlorophenyl)-5-oxotetrahydrofuran-3-yl)-4-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: magnesium chloride / tert-butyl alcohol / 40 °C / Inert atmosphere

2: (3aR,3a'R,8aS,8a'S)-2,2'-(propane-2,2-diyl)bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole); copper(II) bis(trifluoromethanesulfonate) / chloroform / 30 h / 40 °C / Inert atmosphere; Molecular sieve

3: silica gel / chloroform / 0.17 h / 40 °C / Inert atmosphere; Molecular sieve

With silica gel; copper(II) bis(trifluoromethanesulfonate); magnesium chloride; (3aR,3a'R,8aS,8a'S)-2,2'-(propane-2,2-diyl)bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole); In chloroform; tert-butyl alcohol;
DOI:10.1039/c4cc01944j

Reference yield:

: 89-98-5
2-chloro-benzaldehyde

: 1613157-27-9
N-((2S,3R)-2-(2-chlorophenyl)-5-oxotetrahydrofuran-3-yl)-4-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2: magnesium chloride / tert-butyl alcohol / 40 °C / Inert atmosphere

3: (3aR,3a'R,8aS,8a'S)-2,2'-(propane-2,2-diyl)bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole); copper(II) bis(trifluoromethanesulfonate) / chloroform / 30 h / 40 °C / Inert atmosphere; Molecular sieve

4: silica gel / chloroform / 0.17 h / 40 °C / Inert atmosphere; Molecular sieve

With potassium tert-butylate; silica gel; copper(II) bis(trifluoromethanesulfonate); magnesium chloride; (3aR,3a'R,8aS,8a'S)-2,2'-(propane-2,2-diyl)bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole); In tetrahydrofuran; chloroform; tert-butyl alcohol;
DOI:10.1039/c4cc01944j