1255944-55-8

Basic information

• Product Name: (E)-4-(2-chlorophenyl)but-3-enoic acid
• Synonyms: (E)-4-(2-chlorophenyl)but-3-enoic acid
• CAS NO: 1255944-55-8
• Molecular Weight: 196.633
• Mol File: 1255944-55-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (E)-4-(2-chlorophenyl)but-3-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-(2-chlorophenyl)but-3-enoic acid(1255944-55-8)
• EPA Substance Registry System: (E)-4-(2-chlorophenyl)but-3-enoic acid(1255944-55-8)

Safety Data

• Hazardous Substances Data: 1255944-55-8(Hazardous Substances Data)

Upstream product

• 625-38-7 but-3-enoic acid 
• 5906-98-9 N-amino-o-chlorobenzenesulfonamide 
• 89-98-5 2-chloro-benzaldehyde 
• 51114-94-4 (2-carboxyethyl)triphenylphosphonium bromide 
• 36626-29-6 (2-carboxyethyl)triphenylphosphonium chloride 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 57486-68-7 methyl (2-chlorophenyl)acetate 
• 141-82-2 malonic acid 
• 4251-63-2 (2-chlorophenyl)acetaldehyde 
• 1794-45-2 (E)-3-(2-chlorophenyl)propenal 

Downstream Products

• 1039434-24-6 (E)-methyl 2-diazo-4-(2-chlorophenyl)but-3-enoate 
• 1454283-87-4 5-benzyl 2-methyl 4-(2-chlorophenyl)-6-methylpyridine-2,5-dicarboxylate 
• 1454283-64-7 (E)-methyl 4-(2-chlorophenyl)but-3-enoate 
• 1613157-27-9 N-((2S,3R)-2-(2-chlorophenyl)-5-oxotetrahydrofuran-3-yl)-4-nitrobenzenesulfonamide 
• 1613157-19-9 tert-butyl (E)-4-(2-chlorophenyl)but-3-enoate 

Relevant articles and documents

SULFAMATE DERIVATIVE COMPOUNDS FOR USE IN TREATING OR ALLEVIATING A PSYCHIATRIC DISORDER

The present invention relates to a pharmaceutical composition for treating and/or alleviating a psychiatric disorder comprising a sulfamate derivative compound and/or a pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a pharmaceutical composition for inducing anti-stress, anti-anxiety and/or anti-depressant activities comprising a sulfamate derivative compound and/or a pharmaceutically acceptable salt thereof as an active ingredient.

Stereoselective synthesis of 3,4-di-substituted mercaptolactones via photoredox-catalyzed radical addition of thiophenols

A visible light mediated radical addition of thiophenols on 4-phenylbut-3-enoic acids to give diastereoselective synthesis of 3,4-disubstituted γ-lactones is reported. The reaction precludes the conventional prerequisite of conjugate addition. Furthermore, the lactones were successfully utilized in the synthesis of γ-ketoamides.

Efficient Pd-Catalyzed Regio- and Stereoselective Carboxylation of Allylic Alcohols with Formic Acid

Formic acid is efficiently used as a C1 source to directly carboxylate allylic alcohols in the presence of a low loading of palladium catalyst and acetic anhydride as additive to afford β,γ-unsaturated carboxylic acids with excellent chemo-, regio-, and stereoselectivity. The reaction proceeds through a carbonylation process with in situ-generated carbon monoxide under mild conditions, avoiding the use of high-pressure gaseous CO. A bisphosphine ligand with a large bite angle (4,5-bis{diphenylphosphino}-9,9-dimethylxanthene, Xantphos) was found to be uniquely effective for this transformation. The regio- and stereoconvergence of this reaction is ascribed to the thermodynamically favored isomerization of the allylic electrophile in the presence of the palladium catalyst.