Technology Process of Methanesulfonic acid 3-(2-benzyloxy-4-formyl-phenoxy)-3-(3,4-bis-methoxymethoxy-phenyl)-2-hydroxy-propyl ester
There total 5 articles about Methanesulfonic acid 3-(2-benzyloxy-4-formyl-phenoxy)-3-(3,4-bis-methoxymethoxy-phenyl)-2-hydroxy-propyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 96 percent / cc. H2SO4 / 8 h / Heating
2: 1.) sodium hydride (NaH) / 1.) tetrahydrofuran (THF), 0 deg C to room temp., 1 h; 2.) THF, 0 deg C to room temp., 8 h
3: 78 percent / lithium aluminum hydride / diethyl ether; tetrahydrofuran / -10 °C
4: 84 percent / tert-butyl hydroperoxide (70percent), vanadyl acetylacetonate / H2O; CH2Cl2 / 6 h / Ambient temperature
5: 81 percent / aq. sodium hydroxide (1percent) / 2.5 h / 70 °C
6: 72 percent / CH2Cl2; pyridine / 6 h / -10 °C
With
tert.-butylhydroperoxide; sodium hydroxide; lithium aluminium tetrahydride; vanadyl acetylacetonate; sulfuric acid; sodium hydride;
In
tetrahydrofuran; pyridine; diethyl ether; dichloromethane; water;
DOI:10.1248/cpb.35.3603
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) sodium hydride (NaH) / 1.) tetrahydrofuran (THF), 0 deg C to room temp., 1 h; 2.) THF, 0 deg C to room temp., 8 h
2: 78 percent / lithium aluminum hydride / diethyl ether; tetrahydrofuran / -10 °C
3: 84 percent / tert-butyl hydroperoxide (70percent), vanadyl acetylacetonate / H2O; CH2Cl2 / 6 h / Ambient temperature
4: 81 percent / aq. sodium hydroxide (1percent) / 2.5 h / 70 °C
5: 72 percent / CH2Cl2; pyridine / 6 h / -10 °C
With
tert.-butylhydroperoxide; sodium hydroxide; lithium aluminium tetrahydride; vanadyl acetylacetonate; sodium hydride;
In
tetrahydrofuran; pyridine; diethyl ether; dichloromethane; water;
DOI:10.1248/cpb.35.3603
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 84 percent / tert-butyl hydroperoxide (70percent), vanadyl acetylacetonate / H2O; CH2Cl2 / 6 h / Ambient temperature
2: 81 percent / aq. sodium hydroxide (1percent) / 2.5 h / 70 °C
3: 72 percent / CH2Cl2; pyridine / 6 h / -10 °C
With
tert.-butylhydroperoxide; sodium hydroxide; vanadyl acetylacetonate;
In
pyridine; dichloromethane; water;
DOI:10.1248/cpb.35.3603
