Technology Process of 4-(diphenylmethyleneamino)-7-fluoro-2,3-dihydro-1H-inden-2-ol
There total 5 articles about 4-(diphenylmethyleneamino)-7-fluoro-2,3-dihydro-1H-inden-2-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: aluminum (III) chloride; bromine / 16 h / 65 °C
2: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C
3: toluene-4-sulfonic acid / toluene / 2 h / Reflux
4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 °C
5: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / 0 - 20 °C
6: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / toluene / 16 h / 85 °C
With
aluminum (III) chloride; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium(0); lithium aluminium tetrahydride; bromine; caesium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C
2: toluene-4-sulfonic acid / toluene / 2 h / Reflux
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 °C
4: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / 0 - 20 °C
5: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / toluene / 16 h / 85 °C
With
sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium(0); lithium aluminium tetrahydride; caesium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: toluene-4-sulfonic acid / toluene / 2 h / Reflux
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 °C
3: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / 0 - 20 °C
4: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / toluene / 16 h / 85 °C
With
tris-(dibenzylideneacetone)dipalladium(0); lithium aluminium tetrahydride; caesium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; diethyl ether; dichloromethane; toluene;
