C₃₀H₃₀F₃N₉O

Base Information

• Chemical Name: C₃₀H₃₀F₃N₉O
• CAS No.: 1408000-03-2
• Molecular Formula: C₃₀H₃₀F₃N₉O
• Molecular Weight: 589.623
• Mol file: 1408000-03-2.mol

Synonyms:

Chemical Property of C₃₀H₃₀F₃N₉O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₃₀F₃N₉O

There total 8 articles about C₃₀H₃₀F₃N₉O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

5-ethynyl-1H-pyrazolo[3,4-b]pyridine (1207351-15-2) + (R)-3-azido-N-(4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide (1408000-43-0) → C30H30F3N9O (1408000-03-2)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol; at 90 ℃;

DOI:10.1021/jm301188x

Reference yield:

tert-butyl N-[4-methyl-3-(trifluoromethyl)phenyl]carbamate (1408000-39-4) → C30H30F3N9O (1408000-03-2)

Guidance literature:

Multi-step reaction with 5 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux

2: triethylamine / tetrahydrofuran / 50 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: potassium tert-butylate / tetrahydrofuran / -20 - 20 °C

5: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 90 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; copper(II) sulfate; sodium L-ascorbate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; tert-butyl alcohol;

DOI:10.1021/jm301188x

Reference yield:

tert-butyl N-[4-(bromomethyl)-3-(trifluoromethyl)phenyl]carbamate (1408000-40-7) → C30H30F3N9O (1408000-03-2)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 50 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: potassium tert-butylate / tetrahydrofuran / -20 - 20 °C

4: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 90 °C

With potassium tert-butylate; copper(II) sulfate; sodium L-ascorbate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;

DOI:10.1021/jm301188x

upstream raw materials:

tert-butyl N-[4-methyl-3-(trifluoromethyl)phenyl]carbamate

tert-butyl N-[4-(bromomethyl)-3-(trifluoromethyl)phenyl]carbamate

methyl 3-azido-4-methylbenzoate

[(R)-1-(4-amino-2-trifluoromethyl-benzyl)-pyrrolidin-3-yl]-dimethyl-amine