(2R,4R)-4-{2-Isobutyrylamino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-pyrrolidine-1,2-dicarboxylic acid 2-benzhydryl ester 1-tert-butyl ester

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Chemical Name:(2R,4R)-4-{2-Isobutyrylamino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-pyrrolidine-1,2-dicarboxylic acid 2-benzhydryl ester 1-tert-butyl ester
CAS No.:189163-82-4
Molecular Formula:C₄₀H₄₃N₇O₈
Molecular Weight:749.824
Hs Code.:

(2R,4R)-4-{2-Isobutyrylamino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-pyrrolidine-1,2-dicarboxylic acid 2-benzhydryl ester 1-tert-butyl ester

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Chemical Property of (2R,4R)-4-{2-Isobutyrylamino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-pyrrolidine-1,2-dicarboxylic acid 2-benzhydryl ester 1-tert-butyl ester

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Technology Process of (2R,4R)-4-{2-Isobutyrylamino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-pyrrolidine-1,2-dicarboxylic acid 2-benzhydryl ester 1-tert-butyl ester

There total 5 articles about (2R,4R)-4-{2-Isobutyrylamino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-pyrrolidine-1,2-dicarboxylic acid 2-benzhydryl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135042-12-5,946610-68-0
(4R)-1-(tert-butoxycarbonyl)-4-hydroxy-D-proline

: 189163-82-4
(2R,4R)-4-{2-Isobutyrylamino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-pyrrolidine-1,2-dicarboxylic acid 2-benzhydryl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / ethyl acetate / Ambient temperature

2: PPh₃, DEAD / tetrahydrofuran / Ambient temperature

3: conc. aq. NH₃ / methanol / 1 h / Ambient temperature

4: PPh₃, DEAD / dioxane / 36 h / Ambient temperature

With ammonium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate;
DOI:10.1039/a603699f

Reference yield:

: 908093-98-1
diazodiphenylmethane

: 189163-82-4
(2R,4R)-4-{2-Isobutyrylamino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-pyrrolidine-1,2-dicarboxylic acid 2-benzhydryl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / ethyl acetate / Ambient temperature

2: PPh₃, DEAD / tetrahydrofuran / Ambient temperature

3: conc. aq. NH₃ / methanol / 1 h / Ambient temperature

4: PPh₃, DEAD / dioxane / 36 h / Ambient temperature

With ammonium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate;
DOI:10.1039/a603699f

Reference yield:

: 189163-79-9
(2R,4S)-4-Formyloxy-pyrrolidine-1,2-dicarboxylic acid 2-benzhydryl ester 1-tert-butyl ester

: 189163-82-4
(2R,4R)-4-{2-Isobutyrylamino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-pyrrolidine-1,2-dicarboxylic acid 2-benzhydryl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: conc. aq. NH₃ / methanol / 1 h / Ambient temperature

2: PPh₃, DEAD / dioxane / 36 h / Ambient temperature

With ammonium hydroxide; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; methanol;
DOI:10.1039/a603699f