Technology Process of rel-(3aS,5R,6S,7aS)-6-acetoxymethyl-5-phenylseleno-3,3a,5,6,7,7a-hexahydrobenzofuran-2,4-dione
There total 10 articles about rel-(3aS,5R,6S,7aS)-6-acetoxymethyl-5-phenylseleno-3,3a,5,6,7,7a-hexahydrobenzofuran-2,4-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
ethyl acetate;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 94 percent / N-ethyldi-isopropylamine / CH2Cl2 / 72 h / Ambient temperature
2: 99 percent / toluene-p-sulphonic acid / 1 h / Ambient temperature
3: 100 percent / 1M aq.potassium hydroxide / 0.25 h / 50 °C
4: 70 percent / lithium aluminium hydride / diethyl ether / 1./ O gradC, 30 min. 2./ reflux l6h
5: 94 percent / triethylamine / diethyl ether / 8 h / Ambient temperature
6: m-chloroperbenzoic acid / CHCl3 / 1./ -14 gradC, 1h. 2./ room temp. 5h.
7: 100 percent / saturated aq. ammonium chloride / methanol / 2 h / Ambient temperature
9: 70 percent / pyridinium chlorochromate on alumina / CH2Cl2 / 36 h / Ambient temperature
10: 67 percent / ethyl acetate / Ambient temperature
With
potassium hydroxide; lithium aluminium tetrahydride; pyridiniumchlorochromate on aluminumoxide; ammonium chloride; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid;
In
methanol; diethyl ether; dichloromethane; chloroform; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 94 percent / triethylamine / diethyl ether / 8 h / Ambient temperature
2: m-chloroperbenzoic acid / CHCl3 / 1./ -14 gradC, 1h. 2./ room temp. 5h.
3: 100 percent / saturated aq. ammonium chloride / methanol / 2 h / Ambient temperature
5: 70 percent / pyridinium chlorochromate on alumina / CH2Cl2 / 36 h / Ambient temperature
6: 67 percent / ethyl acetate / Ambient temperature
With
pyridiniumchlorochromate on aluminumoxide; ammonium chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
methanol; diethyl ether; dichloromethane; chloroform; ethyl acetate;
