2-(3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-6-(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-aniline

Base Information

• Chemical Name: 2-(3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-6-(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-aniline
• CAS No.: 267881-44-7
• Molecular Formula: C₁₂H₉N₇O₃S
• Molecular Weight: 331.315
• Mol file: 267881-44-7.mol

Synonyms:

Chemical Property of 2-(3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-6-(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-6-(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-aniline

There total 1 articles about 2-(3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-6-(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

thiosemicarbazide (79-19-6) + 7-(6-azauracil-5-yl)-isatine (193603-11-1) → 2-(3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-6-(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-aniline (267881-44-7)

Guidance literature:

7-(6-azauracil-5-yl)-isatine; With potassium hydroxide; for 0.166667h; Heating;

thiosemicarbazide; for 0.25h; Heating;

DOI:10.1002/jhet.5570370119

Reference yield: 85.0%

2-(3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-6-(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-aniline (267881-44-7) → 2,6-bis(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-aniline (193603-13-3)

Guidance literature:

With potassium hydroxide; potassium permanganate; for 0.5h;

DOI:10.1002/jhet.5570370119

Reference yield:

2-(3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-6-(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-aniline (267881-44-7) → 2-[2,6-bis(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile

Guidance literature:

Multi-step reaction with 3 steps

1.1: 85 percent / KMnO₄; aq. KOH / 0.5 h

2.1: NaNO₂; 98 percent H₂SO₄ / 1 h / 0 - 5 °C

2.2: 63.2 percent / aq. NaOH / 0 - 5 °C

3.1: 73.6 percent / pyridine / 12 h / Heating

With pyridine; potassium hydroxide; potassium permanganate; sulfuric acid; sodium nitrite; 1.1: Oxidation / 2.1: Diazotization / 2.2: Condensation / 3.1: Cyclization;

DOI:10.1002/jhet.5570370119

upstream raw materials:

thiosemicarbazide

7-(6-azauracil-5-yl)-isatine

Downstream raw materials:

2,6-bis(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-aniline