193603-13-3

Upstream product

• 193603-12-2 3-carbamoylhydrazono-7-(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-2,3-dihydroindol-2-one 
• 267881-44-7 2-(3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-6-(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)-aniline 
• 193603-11-1 7-(6-azauracil-5-yl)-isatine 
• 25623-56-7 6-(o-aminophenyl)-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione 
• 193603-10-0 6-(2-oximinoacetylaminophenyl)-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione 

Relevant academic research and scientific papers

Synthesis of some polycyclic 1,2,4-triazines disposing of acidic N-H group

7-(6-Azauracil-5-yl)-isatin 1 was convened through its thiosemicarbazone 2 to 6-(6-azauracil-5-yl)-2,3-dihydro-5H-1,2,4-triazino[5,6-b]indol-3-thione 3 and through the thiosemicarbazone of appropriate isatinic acid to 2-(2- thio-6-azauracil-5-yl)-6-(6-azauracil-5-yl)-aniline 4. The course of the cyclocondensation of this compound was studied and the reaction was found to proceed in both possible ways, resulting in a mixture of compound 3 and regioisomer 6-(2-thio-6-azauracil-5-yl)-2,3-dihydro-5H-1,2,4-triazino[5,6- b]indol-3-one 5. Substituted aniline 4 was oxidized to 2,6-bis-(6-azauracil- 5-yl)-aniline 7, which served for the preparation of hydrazone 8, cyclization of which led to 1-[2,6-bis-(6-azauracil-5-yl)-phenyl]-6-azauracil-5- carbonitrile 9. This is the first tricyclic 6-azauracil with vicinal arrangement of 6-azauracil rings.

Cyclocondensation Reactions of Heterocyclic Carbonyl Compounds. [1]. Synthesis of 2,6-bis(6-Azauracil-5-yl)aniline and its Use for Synthesis of Some Other Polynuclear 1,2,4-Triazines

5-(2-Aminophenyl)-6-azauracil 1 was converted to 7-(6-azauracil-5-yl)isatin 3, semicarbazone 4 of which was recyclized to 2,6-bis(6-azauracil-5-yl)aniline 5. This one served as a starting compound for preparation of other noncondensed two nuclear heterocycles 7, 9, 10 and condensed 1,2,4-triazines 11 and 12 as well.