Phosphoric acid (5aS,7R,8S,11aR)-8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-yl ester diphenyl ester

Base Information

Chemical Name:Phosphoric acid (5aS,7R,8S,11aR)-8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-yl ester diphenyl ester
CAS No.:725253-38-3
Molecular Formula:C₃₈H₄₁O₈P
Molecular Weight:656.712
Hs Code.:

Phosphoric acid (5aS,7R,8S,11aR)-8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-yl ester diphenyl ester

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Chemical Property of Phosphoric acid (5aS,7R,8S,11aR)-8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-yl ester diphenyl ester

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Technology Process of Phosphoric acid (5aS,7R,8S,11aR)-8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-yl ester diphenyl ester

There total 5 articles about Phosphoric acid (5aS,7R,8S,11aR)-8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-yl ester diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 725253-47-4
(5aS,7R,8S,11aR)-8-Benzyloxy-7-benzyloxymethyl-decahydro-1,6-dioxa-cycloheptacycloocten-2-one

: 725253-38-3
Phosphoric acid (5aS,7R,8S,11aR)-8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-yl ester diphenyl ester

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃;
DOI:10.1016/j.tetlet.2004.04.083

Reference yield:

: Phosphoric acid (E)-(7S,8R)-7-benzyloxy-8-benzyloxymethyl-5,6,7,8-tetrahydro-4H-oxocin-2-yl ester diphenyl ester

: 725253-38-3
Phosphoric acid (5aS,7R,8S,11aR)-8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-yl ester diphenyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 9-BBN / tetrahydrofuran / 20 °C

1.2: 78 percent / aq. Cs₂CO₃ / PdCl₂(dppf)*CH₂Cl₂ / tetrahydrofuran; dimethylformamide / 50 °C

2.1: thexylborane / tetrahydrofuran / 0 °C

2.2: 100 percent / aq. NaOH; aq. H₂O₂ / tetrahydrofuran / 20 °C

3.1: PPTS / CH₂Cl₂ / 20 °C

4.1: TBAF / tetrahydrofuran / 20 °C

5.1: SO₃*pyridine; Et₃N / dimethylsulfoxide; CH₂Cl₂ / 0 °C

6.1: NaClO₂; NaH₂PO₄; 2-methyl-2-butene / H₂O; 2-methyl-propan-2-ol / 0 - 20 °C

6.2: aq.HCl / H₂O; 2-methyl-propan-2-ol / 20 °C

7.1: 2,4,6-trichlorobenzoyl chloride; Et₃N / tetrahydrofuran / 20 °C

7.2: 94 percent / DMAP / toluene / 110 °C

8.1: KHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

With sodium chlorite; sodium dihydrogenphosphate; 9-borabicyclo[3.3.1]nonane dimer; 2-methyl-but-2-ene; pyridine-SO₃ complex; thexylborane; 2,4,6-trichlorobenzoyl chloride; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2004.04.083

Reference yield:

: 4-[(2S,3R,7S,8R)-7-Benzyloxy-8-benzyloxymethyl-3-(2-ethoxy-ethoxy)-oxocan-2-yl]-butyraldehyde

: 725253-38-3
Phosphoric acid (5aS,7R,8S,11aR)-8-benzyloxy-7-benzyloxymethyl-5,5a,7,8,9,10,11,11a-octahydro-4H-1,6-dioxa-cycloheptacycloocten-2-yl ester diphenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaClO₂; NaH₂PO₄; 2-methyl-2-butene / H₂O; 2-methyl-propan-2-ol / 0 - 20 °C

1.2: aq.HCl / H₂O; 2-methyl-propan-2-ol / 20 °C

2.1: 2,4,6-trichlorobenzoyl chloride; Et₃N / tetrahydrofuran / 20 °C

2.2: 94 percent / DMAP / toluene / 110 °C

3.1: KHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; 2,4,6-trichlorobenzoyl chloride; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; water; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2004.04.083