Phosphoric acid bis-(2-cyano-ethyl) ester (3,5-dimethoxy-phenyl)-[2-(3,5-dimethoxy-phenyl)-[1,3]dioxolan-2-yl]-methyl ester

Base Information

• Chemical Name: Phosphoric acid bis-(2-cyano-ethyl) ester (3,5-dimethoxy-phenyl)-[2-(3,5-dimethoxy-phenyl)-[1,3]dioxolan-2-yl]-methyl ester
• CAS No.: 1027653-91-3
• Molecular Formula: C₂₆H₃₁N₂O₁₀P
• Molecular Weight: 562.513
• Mol file: 1027653-91-3.mol

Synonyms:

Chemical Property of Phosphoric acid bis-(2-cyano-ethyl) ester (3,5-dimethoxy-phenyl)-[2-(3,5-dimethoxy-phenyl)-[1,3]dioxolan-2-yl]-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid bis-(2-cyano-ethyl) ester (3,5-dimethoxy-phenyl)-[2-(3,5-dimethoxy-phenyl)-[1,3]dioxolan-2-yl]-methyl ester

There total 2 articles about Phosphoric acid bis-(2-cyano-ethyl) ester (3,5-dimethoxy-phenyl)-[2-(3,5-dimethoxy-phenyl)-[1,3]dioxolan-2-yl]-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-bis-(3,5-dimethoxyphenyl)-2-hydroxyethanone (144758-76-9) → Phosphoric acid bis-(2-cyano-ethyl) ester (3,5-dimethoxy-phenyl)-[2-(3,5-dimethoxy-phenyl)-[1,3]dioxolan-2-yl]-methyl ester (1027653-91-3)

Guidance literature:

Multi-step reaction with 2 steps

1: p-toluenesulfonic acid / benzene / 16 h / Heating

2: 1.) 1H-tetrazole, 2.) m-chloroperbenzoic acid / 1.) THF, r.t., 1.5 h, 2.) THF, CH₂Cl₂, 4 deg C, 1 h

With 1H-tetrazole; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In benzene;

Reference yield:

bis(2-cyanoethyl) diisopropylamidophosphite (102690-88-0) + 2-(3,5-Dimethoxyphenyl)-2-(α-hydroxy-3,5-dimethoxybenzyl)-1,3-dioxolane (144758-86-1) → Phosphoric acid bis-(2-cyano-ethyl) ester (3,5-dimethoxy-phenyl)-[2-(3,5-dimethoxy-phenyl)-[1,3]dioxolan-2-yl]-methyl ester (1027653-91-3)

Guidance literature:

With 1H-tetrazole; 3-chloro-benzenecarboperoxoic acid; Multistep reaction; 1.) THF, r.t., 1.5 h, 2.) THF, CH₂Cl₂, 4 deg C, 1 h;

Reference yield:

Phosphoric acid bis-(2-cyano-ethyl) ester (3,5-dimethoxy-phenyl)-[2-(3,5-dimethoxy-phenyl)-[1,3]dioxolan-2-yl]-methyl ester (1027653-91-3) → Phosphoric acid mono-{(3,5-dimethoxy-phenyl)-[2-(3,5-dimethoxy-phenyl)-[1,3]dioxolan-2-yl]-methyl} ester (1027303-18-9)

Guidance literature:

With sodium hydroxide; at 50 ℃; for 0.5h;

upstream raw materials:

bis(2-cyanoethyl) diisopropylamidophosphite

2-(3,5-Dimethoxyphenyl)-2-(α-hydroxy-3,5-dimethoxybenzyl)-1,3-dioxolane

1,2-bis-(3,5-dimethoxyphenyl)-2-hydroxyethanone

Downstream raw materials:

Phosphoric acid mono-{(3,5-dimethoxy-phenyl)-[2-(3,5-dimethoxy-phenyl)-[1,3]dioxolan-2-yl]-methyl} ester

1,2-Bis(3,5-dimethoxyphenyl)-2-oxoethyl dihydrogen phosphate