2-oxo-3-(benzyloxy)-4-methoxy-7α-methyl-8β-<<2-(trimethylsilyl)ethoxy>methoxy>-10α-<(tert-butyldimethylsiloxy)methyl>-1α-oxaspiro<4.5>dec-3-ene

Base Information

Chemical Name:2-oxo-3-(benzyloxy)-4-methoxy-7α-methyl-8β-<<2-(trimethylsilyl)ethoxy>methoxy>-10α-<(tert-butyldimethylsiloxy)methyl>-1α-oxaspiro<4.5>dec-3-ene
CAS No.:100297-56-1
Molecular Formula:C₃₁H₅₂O₇Si₂
Molecular Weight:592.921
Hs Code.:

2-oxo-3-(benzyloxy)-4-methoxy-7α-methyl-8β-<<2-(trimethylsilyl)ethoxy>methoxy>-10α-<(tert-butyldimethylsiloxy)methyl>-1α-oxaspiro<4.5>dec-3-ene

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Chemical Property of 2-oxo-3-(benzyloxy)-4-methoxy-7α-methyl-8β-<<2-(trimethylsilyl)ethoxy>methoxy>-10α-<(tert-butyldimethylsiloxy)methyl>-1α-oxaspiro<4.5>dec-3-ene

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Technology Process of 2-oxo-3-(benzyloxy)-4-methoxy-7α-methyl-8β-<<2-(trimethylsilyl)ethoxy>methoxy>-10α-<(tert-butyldimethylsiloxy)methyl>-1α-oxaspiro<4.5>dec-3-ene

There total 6 articles about 2-oxo-3-(benzyloxy)-4-methoxy-7α-methyl-8β-<<2-(trimethylsilyl)ethoxy>methoxy>-10α-<(tert-butyldimethylsiloxy)methyl>-1α-oxaspiro<4.5>dec-3-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 100297-56-1
2-oxo-3-(benzyloxy)-4-methoxy-7α-methyl-8β-<<2-(trimethylsilyl)ethoxy>methoxy>-10α-<(tert-butyldimethylsiloxy)methyl>-1α-oxaspiro<4.5>dec-3-ene

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / pyridine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h

2: 61 percent / LiClO₄, MCPBA / diethyl ether / 20 h / 0 °C

3: 1.) CuBr, DMS / 1.) diethyl ether, 0 deg C, 2.) a) diethyl ether, hexane, o deg C, 2 h, b) RT, 3 h

4: 92 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature

With pyridine; dmap; 2,3-dimercapto-succinic acid; lithium perchlorate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; copper(I) bromide; In diethyl ether; dichloromethane;
DOI:10.1021/jo00355a013

Reference yield:

: 100297-50-5,100297-51-6
2-oxo-3-(benzyloxy)-4-methoxy-10-(hydroxymethyl)-1α-oxaspiro<4.5>deca-3,7-diene

: 100297-56-1
2-oxo-3-(benzyloxy)-4-methoxy-7α-methyl-8β-<<2-(trimethylsilyl)ethoxy>methoxy>-10α-<(tert-butyldimethylsiloxy)methyl>-1α-oxaspiro<4.5>dec-3-ene

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / pyridine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h

2: 61 percent / LiClO₄, MCPBA / diethyl ether / 20 h / 0 °C

3: 1.) CuBr, DMS / 1.) diethyl ether, 0 deg C, 2.) a) diethyl ether, hexane, o deg C, 2 h, b) RT, 3 h

4: 92 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature

With pyridine; dmap; 2,3-dimercapto-succinic acid; lithium perchlorate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; copper(I) bromide; In diethyl ether; dichloromethane;
DOI:10.1021/jo00355a013

Reference yield:

: 100297-52-7,100297-53-8
2-oxo-3-(benzyloxy)-4-methoxy-10-<(tert-butyldimethylsiloxy)methyl>-1α-oxaspiro<4.5>deca-3,7-diene

: 100297-56-1
2-oxo-3-(benzyloxy)-4-methoxy-7α-methyl-8β-<<2-(trimethylsilyl)ethoxy>methoxy>-10α-<(tert-butyldimethylsiloxy)methyl>-1α-oxaspiro<4.5>dec-3-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / LiClO₄, MCPBA / diethyl ether / 20 h / 0 °C

2: 1.) CuBr, DMS / 1.) diethyl ether, 0 deg C, 2.) a) diethyl ether, hexane, o deg C, 2 h, b) RT, 3 h

3: 92 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature

With 2,3-dimercapto-succinic acid; lithium perchlorate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; copper(I) bromide; In diethyl ether; dichloromethane;
DOI:10.1021/jo00355a013