1-Cyclohexyl-5-oxopyrrolidine-3-carbonyl chloride

Base Information

• Chemical Name: 1-Cyclohexyl-5-oxopyrrolidine-3-carbonyl chloride
• CAS No.: 1181577-49-0
• Molecular Formula: C₁₁H₁₆ClNO₂
• Molecular Weight: 229.707
• Mol file: 1181577-49-0.mol

Synonyms:

Chemical Property of 1-Cyclohexyl-5-oxopyrrolidine-3-carbonyl chloride

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

1-Cyclohexyl-5-oxopyrrolidine-3-carbonyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Cyclohexyl-5-oxopyrrolidine-3-carbonyl chloride

There total 4 articles about 1-Cyclohexyl-5-oxopyrrolidine-3-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-cyclohexyl-5-oxopyrrolidine-3-carboxylic acid (6304-56-9) → 1-cyclohexyl-5-oxo-pyrrolidine-3-carbonyl chloride (1181577-49-0)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1248/cpb.52.63

Reference yield:

2-methylenesuccinic acid (97-65-4,25119-64-6) → 1-cyclohexyl-5-oxo-pyrrolidine-3-carbonyl chloride (1181577-49-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / 0.5 h / 200 °C

2: oxalyl chloride; DMF / 0.75 h / 0 °C

With oxalyl dichloride; N,N-dimethyl-formamide;

DOI:10.1021/jm060715y

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) → 1-cyclohexyl-5-oxo-pyrrolidine-3-carbonyl chloride (1181577-49-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / 0.5 h / 200 °C

2: oxalyl chloride; DMF / 0.75 h / 0 °C

With oxalyl dichloride; N,N-dimethyl-formamide;

DOI:10.1021/jm060715y

upstream raw materials:

1-cyclohexyl-5-oxopyrrolidine-3-carboxylic acid

2-methylenesuccinic acid

cyclohexylamine

Refernces

• 1、 Imamura, Shinichi,Ishihara, Yuji,Hattori, Taeko,Kurasawa, Osamu,Matsushita, Yoshihiro,Sugihara, Yoshihiro,Kanzaki, Naoyuki,Iizawa, Yuji,Baba, Masanori,Hashiguchi, Shohei. "CCR5 antagonists as anti-HIV-1 agents. 1. Synthesis and biological evaluation of 5-oxopyrrolidine-3-carboxamide derivatives". . p. 63 - 73. Retrieved 2007/10/03.