(2S,3S)-2-Amino-3-(4-hydroxy-phenyl)-butyric acid

Base Information

Chemical Name:(2S,3S)-2-Amino-3-(4-hydroxy-phenyl)-butyric acid
CAS No.:128573-14-8
Molecular Formula:C₁₀H₁₃NO₃
Molecular Weight:195.218
Hs Code.:
DSSTox Substance ID:DTXSID901302145
Nikkaji Number:J565.141G

Synonyms:(2S,3S)-2-Amino-3-(4-hydroxy-phenyl)-butyric acid;(betaS)-beta-Methyl-L-tyrosine;DTXSID901302145;erythro-(2S,3S)-beta-Methyltyrosine;128573-14-8;(2S, 3S)-rel-2-Amino-3-(4-hydroxy-phenyl)-butyric acid

Suppliers and Price of (2S,3S)-2-Amino-3-(4-hydroxy-phenyl)-butyric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (2S,3S)-2-Amino-3-(4-hydroxy-phenyl)-butyric acid

Chemical Property:

Vapor Pressure:3.78E-06mmHg at 25°C
XLogP3:-1.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:195.08954328
Heavy Atom Count:14
Complexity:200

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1=CC=C(C=C1)O)C(C(=O)O)N
Isomeric SMILES:C[C@@H](C1=CC=C(C=C1)O)[C@@H](C(=O)O)N

Technology Process of (2S,3S)-2-Amino-3-(4-hydroxy-phenyl)-butyric acid

There total 39 articles about (2S,3S)-2-Amino-3-(4-hydroxy-phenyl)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.8%

: 132338-27-3
(2R,3R)-2-amino-3-(4-methoxyphenyl)butyric acid

: 128573-10-4,128573-14-8
erythro-D-(2R,3R)-β-Methyltyrosine

Guidance literature:: With ion-exchange resin; hydrogen bromide; sodium iodide; 1.) water, 90-94 deg C;
DOI:10.1016/S0040-4039(00)73917-7

Reference yield:

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 128573-14-8
erythro-β-methyltyrosine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Ac₂O, H₂SO₄, 2.) pyridine / 1.) a) 60 deg C, 15 min, b) RT, overnight, 2.) RT, 10 min

2: 86 percent / NaOMe / 2 h / Ambient temperature

3: 76 percent / H₂ / 10 percent Pd/C / methanol / 4 h / 2585.74 Torr / Ambient temperature

4: 58 percent / 48 percent aq. HBr, AcOH / 24 h / Heating

With pyridine; sulfuric acid; hydrogen bromide; hydrogen; sodium methylate; acetic anhydride; acetic acid; palladium on activated charcoal; In methanol;
DOI:10.1021/jm981011u

Reference yield:

: 57427-93-7
2-phenyl-4-<α-E-p-methoxyphenylethylidene>-5(4H)-oxazolone

: 128573-14-8
erythro-β-methyltyrosine

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / NaOMe / 2 h / Ambient temperature

2: 76 percent / H₂ / 10 percent Pd/C / methanol / 4 h / 2585.74 Torr / Ambient temperature

3: 58 percent / 48 percent aq. HBr, AcOH / 24 h / Heating

With hydrogen bromide; hydrogen; sodium methylate; acetic acid; palladium on activated charcoal; In methanol;
DOI:10.1021/jm981011u