Technology Process of S3I-201.2096
There total 12 articles about S3I-201.2096 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
tetrahydrofuran; methanol;
at 20 ℃;
DOI:10.1002/cmdc.201100194
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 21 h / 0 - 20 °C / Inert atmosphere
2.1: acetic acid / methanol / 3 h / 45 °C / Molecular sieve; Inert atmosphere
2.2: 12 h / 20 °C / Inert atmosphere
3.1: dichlorotriphenylphosphorane / chloroform / 12 h / 60 °C / Inert atmosphere
4.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
5.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere
6.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 20 °C
With
lithium hydroxide monohydrate; palladium 10% on activated carbon; potassium tert-butylate; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; dichlorotriphenylphosphorane;
In
tetrahydrofuran; methanol; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100194
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
2.1: aluminum (III) chloride / dichloromethane / 1 h / 0 °C / Inert atmosphere
3.1: palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine / ethyl acetate / 2 h / 20 °C
4.1: acetic acid / methanol / 3 h / 45 °C / Molecular sieve; Inert atmosphere
4.2: 12 h / 20 °C / Inert atmosphere
5.1: dichlorotriphenylphosphorane / chloroform / 12 h / 60 °C / Inert atmosphere
6.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
7.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere
8.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 20 °C
With
aluminum (III) chloride; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; dichlorotriphenylphosphorane;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; dimethyl sulfoxide; ethyl acetate;
2.1: Friedel Crafts acylation / 3.1: Rosenmund reduction;
DOI:10.1002/cmdc.201100194
