Boc-PheΨGly-ACHPA-Leu-NHCH2Ph

Base Information

• Chemical Name: Boc-PheΨGly-ACHPA-Leu-NHCH2Ph
• CAS No.: 118405-03-1
• Molecular Formula: C₄₁H₆₂N₄O₇
• Molecular Weight: 722.966
• Mol file: 118405-03-1.mol

Synonyms:

Chemical Property of Boc-PheΨGly-ACHPA-Leu-NHCH2Ph

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-PheΨGly-ACHPA-Leu-NHCH2Ph

There total 6 articles about Boc-PheΨGly-ACHPA-Leu-NHCH2Ph which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-PheΨACHPA-Leu-NHCH2Ph (118405-00-8,124338-97-2,124339-25-9) → Boc-PheΨGly-ACHPA-Leu-NHCH2Ph (118405-03-1,124339-01-1,124339-31-7)

Guidance literature:

With hydrogen; nickel; In methanol; at 24 ℃; under 2585.7 Torr;

DOI:10.1021/jm00164a058

Reference yield:

(2E,4R,S,5S)-5-<<(1,1-dimethylethoxy)carbonyl>amino>-4-hydroxy-6-phenyl-2-hexenoic acid (99113-32-3,99113-34-5,118386-98-4) → Boc-PheΨGly-ACHPA-Leu-NHCH2Ph (118405-03-1,124339-01-1,124339-31-7)

Guidance literature:

Multi-step reaction with 2 steps

1: HOBT/DCC, Et₃N / dimethylformamide / 1.) 0 deg C, 0.5 h, 2.) room temp.

2: H₂ / Raney Ni / methanol / 24 °C / 2585.7 Torr

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; nickel; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00164a058

Reference yield:

Methyl (S)-5-<(tert-butoxycarbonyl)amino>-6-phenyl-(E)-3-hexenoate (118457-05-9) → Boc-PheΨGly-ACHPA-Leu-NHCH2Ph (118405-03-1,124339-01-1,124339-31-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 72 h / Ambient temperature

2: 1.1 g / 1 N NaOH / methanol / 2 h / Ambient temperature

3: HOBT/DCC, Et₃N / dimethylformamide / 1.) 0 deg C, 0.5 h, 2.) room temp.

4: H₂ / Raney Ni / methanol / 24 °C / 2585.7 Torr

With sodium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; nickel; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00164a058

upstream raw materials:

Boc-PheΨACHPA-Leu-NHCH2Ph

Methyl (S)-5-<(tert-butoxycarbonyl)amino>-6-phenyl-(E)-3-hexenoate

(2E,4R,S,5S)-5-<<(1,1-dimethylethoxy)carbonyl>amino>-4-hydroxy-6-phenyl-2-hexenoic acid

[3-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-oxiranyl]-acetic acid methyl ester