Technology Process of 4-((2R,4R,5R,6R)-4,5-Bis-methoxymethoxy-6-methyl-tetrahydro-pyran-2-yl)-N,N-diethyl-2-formyl-3-methoxy-benzamide
There total 14 articles about 4-((2R,4R,5R,6R)-4,5-Bis-methoxymethoxy-6-methyl-tetrahydro-pyran-2-yl)-N,N-diethyl-2-formyl-3-methoxy-benzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: K2CO3 / acetone / Ambient temperature
2: IR 120B / methanol / Ambient temperature
3: 1.) BuLi / 1.) THF, - 78 deg C, 1 h
4: H2NSO3H, NaClO2 / acetone; H2O / 12 h / Ambient temperature
5: Et3SiH, CF3COOH / CH2Cl2 / Ambient temperature
6: pyridine / acetonitrile
8: Bu3SnH, AIBN / toluene / 1 h / 80 °C
9: H2 / Pd(OH)2-C / methanol / Ambient temperature
10: i-Pr2NEt / CHCl3 / 1 h / 40 °C
11: 1.) t-BuLi 2.) TMEDA / THF, -78 deg C to r.t., 1.5 h
With
pyridine; triethylsilane; sodium chlorite; n-butyllithium; 2,2'-azobis(isobutyronitrile); N,N,N,N,-tetramethylethylenediamine; IR 120B; aminosulfonic acid; hydrogen; tert.-butyl lithium; tri-n-butyl-tin hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
palladium hydroxide - carbon;
In
methanol; dichloromethane; chloroform; water; acetone; toluene; acetonitrile;
DOI:10.1016/S0040-4039(00)97881-X
- Guidance literature:
-
Multi-step reaction with 11 steps
1: NBS / H2O; acetonitrile / Ambient temperature
2: PCC, MS-3A / CH2Cl2 / Ambient temperature
3: 1.) BuLi / 1.) THF, - 78 deg C, 1 h
4: H2NSO3H, NaClO2 / acetone; H2O / 12 h / Ambient temperature
5: Et3SiH, CF3COOH / CH2Cl2 / Ambient temperature
6: pyridine / acetonitrile
8: Bu3SnH, AIBN / toluene / 1 h / 80 °C
9: H2 / Pd(OH)2-C / methanol / Ambient temperature
10: i-Pr2NEt / CHCl3 / 1 h / 40 °C
11: 1.) t-BuLi 2.) TMEDA / THF, -78 deg C to r.t., 1.5 h
With
pyridine; triethylsilane; sodium chlorite; N-Bromosuccinimide; n-butyllithium; 2,2'-azobis(isobutyronitrile); N,N,N,N,-tetramethylethylenediamine; aminosulfonic acid; hydrogen; tert.-butyl lithium; tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; trifluoroacetic acid;
palladium hydroxide - carbon;
In
methanol; dichloromethane; chloroform; water; acetone; toluene; acetonitrile;
DOI:10.1016/S0040-4039(00)97881-X
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1.) BuLi / 1.) THF, - 78 deg C, 1 h
2: H2NSO3H, NaClO2 / acetone; H2O / 12 h / Ambient temperature
3: Et3SiH, CF3COOH / CH2Cl2 / Ambient temperature
4: pyridine / acetonitrile
6: Bu3SnH, AIBN / toluene / 1 h / 80 °C
7: H2 / Pd(OH)2-C / methanol / Ambient temperature
8: i-Pr2NEt / CHCl3 / 1 h / 40 °C
9: 1.) t-BuLi 2.) TMEDA / THF, -78 deg C to r.t., 1.5 h
With
pyridine; triethylsilane; sodium chlorite; n-butyllithium; 2,2'-azobis(isobutyronitrile); N,N,N,N,-tetramethylethylenediamine; aminosulfonic acid; hydrogen; tert.-butyl lithium; tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
palladium hydroxide - carbon;
In
methanol; dichloromethane; chloroform; water; acetone; toluene; acetonitrile;
DOI:10.1016/S0040-4039(00)97881-X
