2-(2-(2-propyl)-1,3-dioxo-2,8-diazaspiro<4,5>decane-8-yl)ethyl benzilate

Base Information

• Chemical Name: 2-(2-(2-propyl)-1,3-dioxo-2,8-diazaspiro<4,5>decane-8-yl)ethyl benzilate
• CAS No.: 132168-98-0
• Molecular Formula: C₂₇H₃₂N₂O₅
• Molecular Weight: 464.561
• Mol file: 132168-98-0.mol

Synonyms:

Chemical Property of 2-(2-(2-propyl)-1,3-dioxo-2,8-diazaspiro<4,5>decane-8-yl)ethyl benzilate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(2-propyl)-1,3-dioxo-2,8-diazaspiro<4,5>decane-8-yl)ethyl benzilate

There total 5 articles about 2-(2-(2-propyl)-1,3-dioxo-2,8-diazaspiro<4,5>decane-8-yl)ethyl benzilate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methyl benzilate (76-89-1) + 8-(2-hydroxyethyl)-2-(2-propyl)-2,8-diazaspiro<4,5>decane-1,3-dione (132168-95-7) → 2-(2-(2-propyl)-1,3-dioxo-2,8-diazaspiro<4,5>decane-8-yl)ethyl benzilate (132168-98-0)

Guidance literature:

With sodium methylate; In toluene; for 4h; Heating;

Reference yield: 56.0%

benzilic acid sodium salt (13154-93-3) + 8-(2-chloroethyl)-2-(2-propyl)-2,8-diazaspiro<4,5>decane-1,3-dione (132168-96-8) → 2-(2-(2-propyl)-1,3-dioxo-2,8-diazaspiro<4,5>decane-8-yl)ethyl benzilate (132168-98-0)

Guidance literature:

In isopropyl alcohol; for 8h; Heating;

Reference yield:

1-Benzyl-4-(carboxymethyl)-4-piperidinecarboxylic acid hydrochloride (40117-95-1) → 2-(2-(2-propyl)-1,3-dioxo-2,8-diazaspiro<4,5>decane-8-yl)ethyl benzilate (132168-98-0)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂O / 160 - 200 °C

2: 93 percent / H₂ / 5percent Pd/C / methanol / 760 Torr

3: Na₂CO₃ / CHCl₃ / 13 h / Heating

4: 70 percent / sodium methoxide / toluene / 4 h / Heating

With hydrogen; sodium methylate; sodium carbonate; palladium on activated charcoal; In methanol; chloroform; water; toluene;

upstream raw materials:

methyl benzilate

8-(2-hydroxyethyl)-2-(2-propyl)-2,8-diazaspiro<4,5>decane-1,3-dione

benzilic acid sodium salt

8-(2-chloroethyl)-2-(2-propyl)-2,8-diazaspiro<4,5>decane-1,3-dione