Technology Process of tert-butyl N-(4-{5-[2-(methoxymethyl)-2'-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycinate
There total 10 articles about tert-butyl N-(4-{5-[2-(methoxymethyl)-2'-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycinate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetonitrile / 15 h / 20 °C
2.1: hydroxylamine hydrochloride / water; ethanol / 15 h / 20 °C
3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 20 °C
3.2: 3 h / 20 °C
4.1: toluene; N,N-dimethyl-formamide / 15 h / 95 °C
With
hydroxylamine hydrochloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1002/cmdc.201402557
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydroxylamine hydrochloride / water; ethanol / 15 h / 20 °C
2.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 20 °C
2.2: 3 h / 20 °C
3.1: toluene; N,N-dimethyl-formamide / 15 h / 95 °C
With
hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201402557
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chloroform / 48 h / 70 °C / Inert atmosphere
2.1: 96 h / Reflux
3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; toluene / 1 h / 110 °C / Inert atmosphere
4.1: sodium hydroxide / ethanol / 1 h / 60 °C
5.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 20 °C
5.2: 3 h / 20 °C
6.1: toluene; N,N-dimethyl-formamide / 15 h / 95 °C
With
N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); 2,2'-azobis(isobutyronitrile); potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide;
In
ethanol; chloroform; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201402557
