C₂₆H₂₇N₃O₄

Base Information

• Chemical Name: C₂₆H₂₇N₃O₄
• CAS No.: 1312782-04-9
• Molecular Formula: C₂₆H₂₇N₃O₄
• Molecular Weight: 445.518
• Mol file: 1312782-04-9.mol

Synonyms:

Chemical Property of C₂₆H₂₇N₃O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₇N₃O₄

There total 10 articles about C₂₆H₂₇N₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-cyano-1-ethoxycarbonylmethyl-8-methyl-1-propyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indole-7-carboxylic acid (630400-06-5) → C26H27N3O4 (1312782-04-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-methyl-morpholine; HATU / dichloromethane

2: water; sodium hydroxide / ethanol

With 4-methyl-morpholine; water; HATU; sodium hydroxide; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2011.04.052

Reference yield:

5-bromo-2-methyl-3-nitro-benzoic acid (107650-20-4) → C26H27N3O4 (1312782-04-9)

Guidance literature:

Multi-step reaction with 9 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

2: iron; ammonium chloride / water / 100 °C

3: hydrogenchloride; sodium nitrite

4: tin(ll) chloride

5: zinc(II) chloride / water; ethylene glycol / 100 °C

6: 1-methyl-pyrrolidin-2-one / 190 °C

7: hydrogen; palladium(II) hydroxide / methanol; ethyl acetate

8: 4-methyl-morpholine; HATU / dichloromethane

9: water; sodium hydroxide / ethanol

With 4-methyl-morpholine; hydrogenchloride; water; hydrogen; palladium(II) hydroxide; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; tin(ll) chloride; sodium hydroxide; zinc(II) chloride; sodium nitrite; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; ethylene glycol; ethyl acetate;

DOI:10.1016/j.bmcl.2011.04.052

Reference yield:

C15H15BrN2O2 (788820-59-7) → C26H27N3O4 (1312782-04-9)

Guidance literature:

Multi-step reaction with 5 steps

1: zinc(II) chloride / water; ethylene glycol / 100 °C

2: 1-methyl-pyrrolidin-2-one / 190 °C

3: hydrogen; palladium(II) hydroxide / methanol; ethyl acetate

4: 4-methyl-morpholine; HATU / dichloromethane

5: water; sodium hydroxide / ethanol

With 4-methyl-morpholine; water; hydrogen; palladium(II) hydroxide; HATU; sodium hydroxide; zinc(II) chloride; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; ethylene glycol; ethyl acetate;

DOI:10.1016/j.bmcl.2011.04.052

upstream raw materials:

5-bromo-2-methyl-3-nitro-benzoic acid

5-Bromo-2-methyl-3-nitrobenzoic acid benzyl ester

3-Amino-5-bromo-2-methylbenzoic acid benzyl ester

C₁₅H₁₅BrN₂O₂