phenyl-N₂-isobutyryl-2'-deoxyguanosine-3'-monophosphate

Base Information

• Chemical Name: phenyl-N₂-isobutyryl-2'-deoxyguanosine-3'-monophosphate
• CAS No.: 1360780-31-9
• Molecular Formula: C₂₀H₂₄N₅O₈P
• Molecular Weight: 493.413
• Mol file: 1360780-31-9.mol

Synonyms:

Chemical Property of phenyl-N₂-isobutyryl-2'-deoxyguanosine-3'-monophosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl-N₂-isobutyryl-2'-deoxyguanosine-3'-monophosphate

There total 5 articles about phenyl-N₂-isobutyryl-2'-deoxyguanosine-3'-monophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C41H42N5O10P (167147-37-7) → phenyl-N2-isobutyryl-2'-deoxyguanosine-3'-monophosphate (1360780-31-9)

Guidance literature:

With methanol; trichloroacetic acid; In dichloromethane; at 20 ℃; for 0.0333333h;

DOI:10.1021/jo202505h

Reference yield:

[5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-2'-deoxyguanosine-3'-yl]-(N,N'-diisopropyl)methylphosphoramidite (84416-84-2) → phenyl-N2-isobutyryl-2'-deoxyguanosine-3'-monophosphate (1360780-31-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1H-tetrazole / 1,4-dioxane; acetonitrile / 3.12 h / 5 - 20 °C / Molecular sieve; Sonication

2: tert.-butylhydroperoxide / 1,4-dioxane; decane; acetonitrile / 0.25 h / 5 °C

3: 1-Naphthalenethiol; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; water / 0.25 h / 20 °C

4: methanol; trichloroacetic acid / dichloromethane / 0.03 h / 20 °C

With 1H-tetrazole; methanol; tert.-butylhydroperoxide; 1-Naphthalenethiol; N-ethyl-N,N-diisopropylamine; trichloroacetic acid; In tetrahydrofuran; 1,4-dioxane; decane; dichloromethane; water; acetonitrile;

DOI:10.1021/jo202505h

Reference yield:

C42H44N5O9P → phenyl-N2-isobutyryl-2'-deoxyguanosine-3'-monophosphate (1360780-31-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tert.-butylhydroperoxide / 1,4-dioxane; decane; acetonitrile / 0.25 h / 5 °C

2: 1-Naphthalenethiol; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; water / 0.25 h / 20 °C

3: methanol; trichloroacetic acid / dichloromethane / 0.03 h / 20 °C

With methanol; tert.-butylhydroperoxide; 1-Naphthalenethiol; N-ethyl-N,N-diisopropylamine; trichloroacetic acid; In tetrahydrofuran; 1,4-dioxane; decane; dichloromethane; water; acetonitrile;

DOI:10.1021/jo202505h

upstream raw materials:

methylphenyl N₂-isobutyryl-2'-deoxy-5'-O-dimethoxytritylguanosine-3'-monophosphate

C₄₁H₄₂N₅O₁₀P

[5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2'-deoxyguanosine-3'-yl]-(N,N'-diisopropyl)methylphosphoramidite

phenol

Downstream raw materials:

phenyl 2'-deoxyguanosine-3'-monophosphate